Background. Antihypertensive agents have been shown to inhibit oxidative stress and inflammatory response and thus neuroprotection in Parkinson's disease (PD). Epidemiological evidence suggests inconsistency between use of antihypertensives and risk of PD. This study is aimed to examine the association between antihypertensive use and risk of PD. Methods. Literature search in PubMed, EMBASE, an...

Angiotensin receptor blockers (ARBs) have become established as a major class of antihypertensive on the basis of their powerful effects on blood pressure (BP), excellent tolerability and pleiotropic end-organ-protective effects. However, individual ARBs vary in antihypertensive efficacy, which may be important to clinical outcome. Several strategies are available to ensure that BP reductions w...

j 1 demonstrated the potentiation of antihypertensive agents by chlorothiazide,1-3 its value alone in patients with moderately severe and severe hypertension has not been established. This investigation was designed to compare the effectiveness of alternate 6-month courses of chlorothiazide alone with standard antihypertensive therapy, and to compare the results of these periods with those of a...