We have reported previously the isolation and characterization of a Chinese hamster ovary cell line, designated CHO-Chlr, which exhibits resistance to bifunctional nitrogen mustards while maintaining sensitivity to a range of other alkylating agents and chemotherapeutic drugs. This enhanced drug resistance is associated with a greater than 40-fold increase in the level of expression of an alpha...

Topical photoallergic contact dermatitis (PACD) is investigated by photopatch testing, and a consensus European methodology exists, which advises the use of ultraviolet (UV)A as the irradiation source (1). However, for most agents, the action spectrum for PACD has not been defined. We sought to determine the action spectrum for topical photocontact allergy to the non-steroidal antiinflammatory ...

Sulphonamides are the first effective chemotherapeutic agents used for bacterial infection in humans. Sulfonamides have a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, anti retroviral, anti cancer, antiinflammatory, and used as diuretic. This review consists of a discussion on the...

Autoimmune diseases are numerous and heterogeneous, with a broad spectrum of clinical presentations and unpredictable courses. Treatment options include such medications as analgesics and nonsteroidal antiinflammatory drugs, disease-modifying antirheumatic drugs, biological agents, and glucocorticoids. If the disease is diagnosed early, the major treatment goal is remission with no active infla...

The identification of selective glucocorticoid receptor (GR) modifiers, which separate transactivation and transrepression properties, represents an important research goal for steroid pharmacology. Although the gene-activating properties of GR are mainly associated with undesirable side effects, its negative interference with the activity of transcription factors, such as NF-kappaB, greatly co...

Abstract Introduction: The aim of this study was to investigate the antinociceptive and antiinflammatory effects of Teucrium hyrcanicum aqueous extract in male mice and rats. Methods: To assess the antiinflammatory effect, we used carrageenan- and dextran-induced paw oedema and for determination of the antinociceptive effect, acetic acid-induced writhing, tail flick and formalin pain tests ...