antimalaria

Yuanzheng He Yong Xu Chenghai Zhang Xiang Gao Karl J Dykema Katie R Martin Jiyuan Ke Eric A Hudson Sok Kean Khoo James H Resau Arthur S Alberts Jeffrey P MacKeigan Kyle A Furge H Eric Xu

The antimalaria drug chloroquine has been used as an anti-inflammatory agent for treating systemic lupus erythematosus and rheumatoid arthritis. We report that chloroquine promoted the transrepression of proinflammatory cytokines by the glucocorticoid receptor (GR). In a mouse collagen-induced arthritis model, chloroquine enhanced the therapeutic effects of glucocorticoid treatment. By inhibiti...

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Structural characterization of the erythrocyte binding domain of the reticulocyte binding protein homologue family of Plasmodium yoelii.

Journal: :Infection and immunity 2011

Ardina Grüber Karthigayan Gunalan Jeya Kumar Ramalingam Malathy S S Manimekalai Gerhard Grüber Peter R Preiser

Invasion of the host cell by the malaria parasite is a key step for parasite survival and the only stage of its life cycle where the parasite is extracellular, and it is therefore a target for an antimalaria intervention strategy. Multiple members of the reticulocyte binding protein homologues (RH) family are found in all plasmodia and have been shown to bind to host red blood cells directly. I...

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