In a recent review of thyroid dysfunction induced by antineoplastic agents, Hamnvik et al. (1) highlighted hypothyroidism as a common side effect of certain anticancer agents, an effect with the potential for favorably modifying outcomes in cancer patients. The article indicates that spontaneous or intentionally induced hypothyroidism may be associated with better clinical response rates and lo...

Drug-drug interactions can be a serious complication of taking multiple medications and account for 3% to 5% of all in-hospital medication errors.1 The consequences of drug interactions vary, ranging from excessive blood levels causing drug toxicities to therapeutic failures following sub-optimal blood levels. While the advent of highly active antiretroviral therapy (HAART) for the treatment of...

Neoplastic disorders are one of the most widely spread diseases over the world. There are more than 1 million new cases of cancer registered in the world every year. Therefore, searching for new potential antineoplastic agents is very important task. Computer-aided approaches are widely used for this purpose. To find new agents possessing the required activities, we used a computer program PASS...

Several factors can limit the use of therapeutic drug monitoring (TDM) for cancer chemotherapeutic agents, including poorly defined concentration-effect relationships for many antineoplastic agents. This is further complicated by cancer being a highly heterogeneous group of diseases, each of which may have a unique concentration-effect relationship for any given drug or drug combination. Noneth...