Reactive oxygen species (ROS) contribute to the formation and persistence of multiple sclerosis (MS) lesions by acting on distinct pathological processes. In the initial phase of MS lesion development, locally produced ROS may induce blood-brain barrier disruption and enhance leukocyte migration and myelin phagocytosis. In advanced stages, ROS may contribute to lesion persistence by mediating o...

Normal cells are protected by antioxidant enzymes from the toxic effects of high concentrations of reactive oxygen species generated during cellular metabolism. Even though cancer cells generate reactive oxygen species, it has been demonstrated biochemically that antioxidant enzyme levels are low in most animal and human cancers. However, a few cancer types have been found to have elevated leve...

Using pharmacological and biochemical approaches, the role of maize polyamine oxidase (MPAO) in abscisic acid (ABA)-induced antioxidant defense in leaves of maize (Zea mays L.) plants was investigated. Exogenous ABA treatment enhanced the expression of the MPAO gene and the activities of apoplastic MPAO. Pretreatment with two different inhibitors for apoplastic MPAO partly reduced hydrogen pero...

Background: Probiotics have attracted a great attention aiming to develop natural non-toxic antioxidants, because of their role in decreasing the risk of reactive oxygen species (ROS) accumulation. Objectives: The purpose of this study was to assess the antioxidant activity of a probiotic Streptococcus salivarius ssp thermophillus (St.sa) and to evaluate its protective effect against the ...

In this research the effect of salicylic acid (SA), acetylsalicylic acid (ASA), and methylsalicylate (MeSA) treatments, applied as a foliar spray during on-tree plum development, on fruit quality attributes, bioactive compounds, antioxidant activity, and the activity of the antioxidant enzymes at harvest and after long-term cold storage was evaluated in two plum cultivars ("Black Splendor", BS,...

this study was aimed to assess of priming effects on soluble proteins and antioxidant enzymes of as a nigella sativa medicinal plant under different levels of salinity and drought. two greenhouse factorial experiments with three replicated randomized complete block design were conducted.treatments included five levels of priming (potassium nitrate 1% and salicylic acid 0.2 mm in 6 hours, potass...

BACKGROUND Observational epidemiological studies of dietary antioxidant intake, serum antioxidant concentration and lung outcomes suggest that lower levels of antioxidant defences are associated with decreased lung function. Another approach to understanding the role of oxidant/antioxidant imbalance in the risk of chronic obstructive pulmonary disease (COPD) is to investigate the role of geneti...