Recent evidence suggests that impaired antioxidant status is involved in oxidative stress associated with diabetes. The main antioxidant enzymes include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). The aim of the present investigation was to evaluate the activities and protein expression of these antioxidant enzymes in streptozotocin-induced diabetes. Furthermore...

Sapodilla is one of the important fruit crops in tropical area which has problem with seed germination. So Manilkara hexandra (kherol) is generally used as a rootstock for sapodilla. This experiment was performed to assess the morphological changes and antioxidant enzymatic activity of Manilkara hexandra seedling under salinity condition. A pot experiment was carried out in a greenhouse using d...

The response of enzymatic (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase, GPX and glutathione reductase, GR) and non-enzymatic responses (glutathione, GSH, oxidized glutathione, GSSG and GSH/GSSG) against acute Cu toxicity (2-90μg/mL for 48h) in different tissues of Lymnaea stagnalis were measured. Incubation conditions for enzymatic activity measurements were optimized for L...

Previous studies in our laboratory reported L-malate as a free radical scavenger in aged rats. To investigate the antioxidant mechanism of L-malate in the mitochondria, we analyzed the change in gene expression of two malate-aspartate shuttle (MAS)-related carried proteins (AGC, aspartate/glutamate carrier and OMC, oxoglutarate/malate carrier) in the inner mitochondrial membrane, and three anti...

This study was conducted to investigate how the activity and expression of certain paramount antioxidant enzymes respond to grape seed extract (GSE) addition in primary muscle cells of goats. Gluteal primary muscle cells (PMCs) isolated from a 3-week old goat were cultivated as an unstressed cell model, or they were exposed to 100 µM H2O2 to establish a H2O2-stimulated cell model. The activitie...

The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induc...

the present experiment was designed to access the effects of methylmercury chloride ( mehgcl) on antioxidant status, protein concentration, lipid peroxidation and hydroperoxidation in brain parts, spinal cord, lung, heart and pancreas of rats. twenty male wistar rats (3 months old) were divided in saline controls (c) and mehgcl-treated group (mmc). treated rats were intoxicated with mmc at a do...

In this study, effect of different levels of dietary protein (25, 35 and 45 per cent) and water salinity (0-3, 12-15 and 32-35 ppt) on antioxidant enzymes of white leg shrimp (Penaeus vannamei) was studied. 324 P.vannamei (with mean weight±SE: 5.55 ± 0.18 gr) were randomly distributed in twenty seven tanks. Experimental shrimps were fed by formulated diets for 56 days and at the end of the expe...

Increased production of reactive oxygen species (ROS) may be a common pathway in atherosclerosis, diabetes, cataract, accelerated ageing, drug toxicities. The protective role of N-acetyl cysteine (NAC)and magnesium(Mg) in gentamicin induced nephrotoxicity was evaluated . 100 albino rats were divided into 5 groups. Sham control (A), Gentamicin group (B), Gentamicin + NAC group(C), Gentamicin + M...