10-bromo-1,8-dihydroxy-9-anthrone (10-bromoanthralin) was synthesized with precise ratio of bromine to anthralin (1.10:1), respectively. With this ratio of the reagents, the reaction is repetitive at any scale. This compound is a highly significant intermediate for the synthesis of many anthralin derivetised antipsoriatic drugs. Bromination at both benzylic and aromatic ring positions of anthra...

Tinea incognita is a dermatophyte infection of the skin whose clinical presentation has been modified by the misuse of steroids or, as has been described recently, calcineurin inhibitors. We report a case of pustular psoriasis treated with an antipsoriatic cream, composed of topical steroids and a vitamin D3 derivative, which gave rise to a tinea incognita. Our case underlines that clinical fea...

BACKGROUND AND OBJECTIVE The antipsoriatic effect of an innovative aerosol foam formulation of fixed combination calcipotriol 50 μg/g (as hydrate; Cal) and betamethasone 0.5 mg/g (as dipropionate; BD) was explored in order to compare the effect with that of the first-line treatment Cal/BD ointment. METHODS This was a Phase IIa, single-centre, investigator-blinded, exploratory study, with intr...

Tinea incognita is a dermatophyte infection of the skin whose clinical presentation has been modified by the misuse of steroids or, as has been described recently, calcineurin inhibitors. We report a case of pustular psoriasis treated with an antipsoriatic cream, composed of topical steroids and a vitamin D3 derivative, which gave rise to a tinea incognita. Our case underlines that clinical fea...