ABSTRACT
 Objective: In this study, it was aimed to prepare nanosuspensions that contains Indomethacin which is a BCS class II drug. To assess the cumulative impact of chosen variables on nanosuspension properties, 34 factorial design applied and particle size distributions were examined.
 Material Method: solvent/antisolvent method used in preparation suspensions. design. Design-Expe...

Lysozyme (LSZ)-loaded poly-L-lactide (PLLA) porous microparticles (PMs) were successfully prepared by a compressed CO₂ antisolvent process in combination with a water-in-oil emulsion process using LSZ as a drug model and ammonium bicarbonate as a porogen. The effects of different drug loads (5.0%, 7.5% and 10.0%) on the surface morphology, particle size, porosity, tapped density and drug releas...

Coating and encapsulation of fine particles with polymer using a supercritical antisolvent (SAS) coating process was investigated in this research. Synthesized submicron silica particles were used as host particles and poly(lactide-co-glycolide) (PLGA), a biodegradable polymer used for controlled release of drugs, was chosen as the coating material. In the SAS coating process a suspension of si...

In this work, a novel membrane crystallization system was used to crystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition. Membrane crystallization seeds were compared with seeds produced by conventional antisolvent addition and polymorphic transformation of a fine powdered sample of piroxicam form I in water. The membrane crystallization process allowed for a con...

The use of supercritical fluids in the area of material processing and for particle formation has been known for several years now. The advantages of supercritical fluid processing include mild operating temperatures, production of solvent free particles and easy micro encapsulation of particles. One of the attractive methods of particle processing using supercritical fluid is the Supercritical...