Phyllanthus niruri L., a well-known medicinal plant, has been used as a folk antitumor remedy in the worldwide scale. However, the antitumor components in P. niruri have not been reported. In order to verify the antitumor components of P. niruri and the plants which have the high content of these components, we isolated the antitumor components with bioguided fraction and isolation, by differen...

Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating with several metals different oxidation states. Complexes widely described the literature actions numerous advantages, such as low cost easy synthesis. They show biological activities, including antimicrobial, antioxidant...

objective(s): juglone is isolated from many species of the juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. here, we evaluated juglone-induced antitumor effect in ovarian cancer skov3 cells. materials and methods: mtt assay was performed to examine juglone anti-proliferative effect. cell cycle and apoptosis were studied using flow cytometry in juglone-tr...

In vitro immunization of spleen cells from normal BALB/c mice with mitomycin C-treated MOPC-315 tumor cells resulted in high levels of in vitro antitumor cytotoxicity, whereas in vitro immunization of spleen cells from mice bearing large s.c. MOPC-315 tumors resulted in virtually no antitumor cytotoxic ity. The inability of immunized tumor bearer spleen cells to mediate in vitro antitumor cytot...

Antitumor effect of PolyI:C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes. According to a recent paper, tumor-infiltrating M2 macrophages are found to become an additional antitumor effector through polyI:C response.

Antitumor drug treatment of hemoblastoses always takes into account the patient comorbidity. Due to frequent cardiovascular pathology and atherosclerosis, patients have take statins along with antitumor treatment. Experimental studies shown that inhibit cholesterol synthesis (necessary for vital activity malignant cells), isoprenylation RAS RHO oncogenes, proliferation leukemic cells. In additi...

10.1016/S1674-6384(14)60042-3 Licorice (the roots of Glycyrrhiza uralensis) is widely-used in Chinese herbal compound prescriptions for its functions of nourishing qi, alleviating pain, tonifying spleen and stomach, eliminating phlegm, relieving coughing, and harmonizing prescriptions. It contains more than 20 triterpenoids and approximately 300 flavonoids. In recent years, many studies have r...

We previously reported that eribulin mesylate (eribulin), a tubulin-binding drug (TBD), could remodel tumor vasculature (i.e. increase tumor vessels and perfusion) in human breast cancer xenograft models. However, the role of this vascular remodeling in antitumor effects is not fully understood. Here, we investigated the effects of eribulin-induced vascular remodeling on antitumor activities in...