The theca interna layer of the ovarian follicle forms during the antral stage of follicle development and lies adjacent to and directly outside the follicular basal lamina. It supplies androgens and communicates with the granulosa cells and the oocyte by extracellular signaling. To better understand developmental changes in the theca interna, we undertook transcriptome profiling of the theca in...

BACKGROUND Hyperandrogenism is the primary manifestation of polycystic ovary syndrome (PCOS), which appears to be caused by excess exposure to androgen. As such, androgenized animal models have been developed and investigated to study the etiology of PCOS. Anti-Mullerian hormone (AMH) is known to be associated with follicle growth, and its levels are two to three times higher in women with PCOS...

Aims and Objectives a To compare the role of pre-induction ovarian volume and antral follicle count in predicting the retrieved oocyte numbers in in-vitro fertilization patients (IVF). b To study the co-relation of ovarian volume with antral follicle count. Methods and Materials: 53 infertile patients were randomly taken in the study. On 2 day of cycle, Transvaginalultrasound was done and pre-i...

In a sexually mature female, primordial follicles continuously leave the arrested pool and undergo the primordial to primary follicle transition. The oocytes increase in size and the surrounding squamous pre-granulosa cells become cuboidal and proliferate to form a layer of cuboidal cells around the growing oocyte. This development of the primordial follicle commits the follicle to undergo the ...

BACKGROUND The aim of this study was to evaluate the effect of doubling the starting dose of gonadotrophins on the ovarian response in IVF patients with a low antral follicle count (AFC). METHODS Fifty-two patients with an AFC of <5 follicles of 2-5 mm diameter before starting their first IVF cycle participated in this randomized controlled trial. They were randomized by opening a sealed enve...

Fluctuating feed resources to beef cows across the production cycle is a proven method for decreasing input costs; however, limiting nutrients during late gestation have been demonstrated to decrease ovarian follicle numbers in female offspring in some studies. We hypothesize that limiting nutrients to mature (Z3 yr) crossbred beef cows during the second and third trimesters would result in dau...

OBJECTIVE To evaluate the ovarian reserve function in female patients with metabolic syndrome (MetS). METHODS This study evaluated 136 subjects, 67 with MetS and 69 controls. Subjects were divided into three age groups. Group I included 49 subjects aged 20-29 years, 22 with MetS and 27 controls; group II included 45 subjects aged 30-39 years, 22 with MetS and 23 controls; and group III includ...

Background: Bisphenol A (BPA), an estrogenic environmental contaminant is also known for oxidative stressinducing effect. The aim of this study was to investigate the effect of vitamin C as an antioxidant on the ovary tissue in adult rats treated with BPA. Materials and Methods: Adult female rats (200 ±20 g) were divided into 4 groups (n=6):control, bisphenol A (60μg/Kg/day) , vitamin C (150 mg...

background:   objective: the aim of this study was to evaluate the in vitro developmental competence of mouse vitrified pre-antral follicles in comparison to isolated pre-antral follicles derived from vitrified ovaries in the presence of alpha lipoic acid (ala).   materials and methods: pre-antral follicles derived from fresh, vitrified-warmed ovarian tissues and vitrified–warmed pre-antral fol...