We aimed to detect novel genes associated with G protein-coupled receptors (GPCRs) in aldosterone-producing adenoma (APA) and elucidate the mechanisms underlying aldosterone production.Microarray analysis targeting GPCR-associated genes was conducted using APA without known mutations (APA-WT) samples (n = 3) and APA with the KCNJ5 mutation (APA-KCNJ5; n = 3). Since gonadotropin-releasing hormon...

Lectin histochemical characteristics of the kidney of normal and streptozotocin (SZ)-induced diabetic APA hamsters were investigated. Paraffin sections of the kidney of animals killed at 1 and 3 months after SZ-injection were stained with the following 10 lectins: PNA, BPA, DBA, SBA, GSA-I, GSA-II, MPA, WGA, UEA-1 and Con A. Renal lectin binding characteristics of normal APA hamsters differed i...

In this paper we present a general formalism for the establishment of the family of selective partial update affine projection algorithms (SPU-APA). The SPU-APA, the SPU regularized APA (SPU-R-APA), the SPU partial rank algorithm (SPU-PRA), the SPU binormalized data reusing least mean squares (SPU-BNDR-LMS), and the SPU normalized LMS with orthogonal correction factors (SPU-NLMS-OCF) algorithms...

BACKGROUND Psoriasis is an inflammatory disease characterized by increased squamous cell proliferation and impaired differentiation. Vitamin D, Calcitriol, and its analogues are successfully used for psoriasis therapy. However, it is unknown why some psoriasis patients are resistant to Vitamin D therapy. Vitamin D mediates its activity by a nuclear receptor. It is suggested that polymorphisms a...

angiotensin converting enzyme (ace; omim: 106180) has an important role in the conversion of angiotensin i to angiotensin ii and degradation of bradykinin. genetic polymorphism i/d (rs4646994) in the gene encoding ace has been well defined. to get more insight into the genetic structure of iranian populations, the distribution of the ace i/d polymorphism among iranians was compared with each ot...

The Rp- and Sp-diastereomers of the phosphorothioate-containing oligonucleotide d[ApAp(S)ApA] have been synthesized. They and the tetramer d[ApApApA] were tested as substrates for staphylococcal nuclease, DNase II and spleen phosphodiesterase. For digestions with DNase I these oligonucleotides were converted to the 5'-phosphorylated derivates. The reactions with the nucleases were analysed by H...

Alternative polyadenylation (APA) is a widespread gene regulatory mechanism that generates mRNAs with different 3'-ends, allowing them to interact with different sets of RNA regulators such as microRNAs and RNA-binding proteins. Recent studies have shown that during development, neural tissues produce mRNAs with particularly long 3'UTRs, suggesting that such extensions might be important for ne...

Cooperatively shared wide-area omputing platforms, su h as PlanetLab, provide a large pool of geographi ally distributed resour es whi h an be utilized for building highly available and s alable servi es. In this thesis, we present me hanisms and models for building autonomi ally s alable and resilient servi es on su h platforms. In su h platforms resour es at a node are allo ated to ompeting u...

Metastasis accounts for the high mortality rate associated with colorectal cancer (CRC), but metastasis regulators are not fully understood. To identify a novel gene involved in tumor metastasis, we used oligonucleotide microarrays, transcriptome distance analyses, and machine learning algorithms to determine links between primary and metastatic colorectal cancers. Aminopeptidase A (APA; also k...