L-DOPA-induced dyskinesia (LID) is one of the main limitations of long term L-DOPA use in Parkinson's disease (PD) patients. We show that chronic L-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit mimicking PD. The stereotypical abnormal involuntary movements were induced by dopamine receptor agonists and attenuated by antidyskinetic agents...

Pediatric cataracts are responsible for more than 1 million childhood blindness in Asia. In developing countries like India, 7.4%–15.3% of childhood blindness is due to cataract.[1] The socioeconomic status of a large proportion of children with cataracts in India precludes reliable rehabilitation with contact lenses for aphakia. It is noteworthy that the Infant Aphakia Treatment Study (IATS)[2...

THE problem of uniocular catcaract witlh good visual acuity in the other eye is an old, but by no means a solved, problem. The established views still upheld by many oplhthalmologists, that such a cataract is best left alone, is based on the observation that the optical correction of unilateral aphakia is not satisfactory, a-s diplopia and general discomfort are exl)erienced. Furthermilore, the...

Post-traumatic aniridia combined with aphakia may be seen after globe injury. Aside from esthetic aspects, partial or total loss of the iris tissue may also be related to various degrees of glare and photophobia. Such patients suffer from severe visual impairment secondary to aphakia. Herein we describe a novel surgical technique for the management of an aphakic eye with traumatic aniridia for ...

We measured ocular alignment in the horizontal direction for 17 monkeys reared under deprivation paradigms that involved monocular defocus, monocular occlusion and optically corrected aphakia coupled with continuous or partial occlusion of the fellow eye. Alignment was measured at 3 and 7 months with a photographic corneal light reflex method. Results showed that a majority of the monkeys in ea...