نتایج جستجو برای: apo e4 polymorphism

تعداد نتایج: 117403  

Journal: :Genetics and molecular research : GMR 2015
Q Chen X D Peng C Q Huang X Y Hu X M Zhang

In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD). This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively. A total of 296 unrelated AD patients and 423 control subject...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1993
L I Katzel J L Fleg M Paidi N Ragoobarsingh A P Goldberg

The apolipoprotein (apo) E4 polymorphism is associated with increased risk for symptomatic coronary artery disease (CAD). This study examines whether the apo epsilon allele is associated with an increased risk for exercise-induced silent myocardial ischemia (SI) in healthy, older (62 +/- 7 years; mean +/- SD), normocholesterolemic, nonsmoking male volunteers. The apo epsilon 4 allele was presen...

Journal: :Stroke 1999
Y Notsu T Nabika H Y Park J Masuda S Kobayashi

BACKGROUND AND PURPOSE Silent brain infarction (SBI) is often found with white matter hyperintensity. A recent genetic study on elderly twins indicated that the susceptibility to white matter hyperintensity was largely determined by genetic factors, implying the existence of genetic susceptibility for SBI as well. We therefore studied 3 genetic polymorphisms in SBI, the deletion/insertion polym...

D.D. Farhud M. Hushmand M. Seyedian M. Younesian M.H. Sanati S.M. Nabavi V. Hadavi,

Background: The apolipoprotein E (APOE) polymorphism is known to affect various neurologic disorders with different effects on the immune system and CNS repair. However, previous studies on possible modulation of the clinical course of multiple sclerosis (MS) by APOE polymorphism have been inconsistent. Objective: To clarify the issue for MS patients' management and future research. Methods: Th...

Journal: :Bioscience trends 2011
Z Zhang B Peng R R Gong L B Gao J Du D Z Fang Y Y Song Y H Li G J Ou

The relation has not been reported consistently between the polymorphisms in the gene of apolipoprotein A5 (APO A5) and coronary artery disease (CAD). To clarify the discrepancy, we conducted a comprehensive search of PubMed and EMBASE for all available casecontrol studies to explore the association between two APO A5 polymorphisms and CAD. Two reviewers independently selected studies. Statisti...

2015
Zülküf Karahan Murat Uğurlu Berzal Uçaman Ali Veysel Uluğ İlyas Kaya Kemal Çevik Önder Öztürk Hikmet Iyem

Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 1999
A M Dart B Cooper

LDL particle sizes and Apo E phenotypes were determined in 212 subjects of whom 51 had angina. LDL diameter was significantly less in subjects with an epsilon2 allele (24.76+/-0.08 vs 24.94+/-0.02 nm, P=0.02), and this was evident for both E2/E3 (24.77+/-0.09 nm) and E2/E4 (24.69+/-0.08 nm) phenotypes. Although there was a negative relation between LDL diameter and plasma triglyceride, the effe...

2014
Khalid Balar Ilham Slassi Bouchra El Moutawakil Mariame El Messal Mustapha El Alaoui Faris Mohamed Yahyaoui Saadia Aidi Ahmed Adlouni Rachida Habbal Sellama Nadifi

In this paper, we focus on the importance of interaction between adverse genetic mutations, and clinical risk factors in the development of ischemic stroke, knowing that this disease is multifactorial common that is affected by a number genetic mutations and environmental factors. The apolipoprotein E4 allele (APO e4), Factor II G20210A prothrombin (blood clotting protein), and Factor V genotyp...

2016
Marta Włodarczyk Małgorzata Wrzosek Grażyna Nowicka Beata Jabłonowska-Lietz

INTRODUCTION Polymorphisms in the cholesterol ester transfer protein (CETP) gene and apolipoprotein AI (apo AI) gene are identified as the most common genetic factors influencing high-density lipoprotein cholesterol (HDL cholesterol) levels. Low HDL cholesterol is an important risk factor for cardiovascular disease. We investigated the effect of the TaqIB polymorphism of the CETP gene and the 7...

Journal: :Journal of neurology, neurosurgery, and psychiatry 2003
Z Szolnoki F Somogyvári A Kondacs M Szabó L Fodor J Bene B Melegh

OBJECTIVES Ischaemic stroke is a frequent heterogeneous multifactorial disease that is affected by a number of genetic mutations and environmental factors. We hypothesised the clinical importance of the interactions between common, unfavourable genetic mutations and clinical risk factors in the development of ischaemic stroke. METHODS The Factor V Leiden G1691A (Leiden V), the prothrombin G20...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید