The optimised design of gas cyclones is of particular relevance for the recovery of highly valuable products, such as in the production of active pharmaceutical ingredients (API) through drying systems such as spray or fluid bed drying [1]. Traditionally, these have been captured with reverse flow gas cyclones, but fine and low density particles remain difficult to capture [2]. Bagfilters, alth...

BACKGROUND This study aimed to examine the quality in oncology registration trials for new drug application (NDA) or supplemental new drug application (sNDA) as extensions of the indications for use in Japan based on Good Clinical Practice (GCP) audit findings. MATERIALS AND METHODS We collected audit reports of on-site GCP inspections for registration trials in 383 NDAs or sNDAs that were re...

 BLENDING: It is most important step for manufacturing of solution dosage form. High speed of mixing may introduce air into the product and slow mixing may not form a satisfactory product.  For mixing step, both mixing time and speed should be evaluated for API and Excipients.  Mixing might produce particle size reduction or polymorphic conversion  During mixing some other factors like typ...

The United States Pharmacopeial Convention (USP) Therapeutic Peptides Expert Panel was formed in 2013 to evaluate quality attributes for synthetic peptides based on currently available regulatory guidance and expectations. Public quality standards for drug products and drug substances are developed by USP and enforceable by FDA. This series of three articles by the Panel explores the current ma...

BACKGROUND The advent of combinatorial chemistry has revived the interest in five-membered heterocyclic rings as scaffolds in pharmaceutical research. They are also the target of modifications in nucleic acid chemistry. Hence, the characterization of their conformational features is of considerable interest. This can be accomplished from the analysis of the 3J(HH) scalar coupling constants. R...

We provide a systematic study of sesquilinear hermitian forms and a new proof of the calculus of some exponential sums defined with quadratic her-mitian forms. The computation of the number of solutions of equations such as Tr Ft/Fs (f (x) + v.x) = 0 or Tr Ft/Fs (f (x)) = a allows us to construct codes and to obtain their parameters.

The main contribution of this communication is the derivation of a generalized form of the Geman & Yang construction for minimization of convex, non-quadratic criteria. The generalization provides means of obtaining a normal matrix with predefined structure. We show that this property can be used to improve the numerical efficiency of edge preserving MRI reconstruction. The improvement is asses...

We describe a new method to generate symplectic diieomorphisms. This method is based on primitive functions, and it was introduced in 24]. We apply the algorithm to the construction of normal forms of KAM tori. A concrete application, developed in detail and implemented numerically, is normal forms near invariant circles.

The traditional Indian medicine-Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. With aging, numerous changes occur in skin, including decrease in tissue cell regeneration, decrease in collagen content, loss of skin elasticity and mechanical strength. We prepared five topical anti-aging formulations using cow ghee, flax seed oil, Ph...

be a trilinear form in R, and let JA denote the ideal of R generated by all the partial derivatives of A. A question that arises from the theory of hyperdeterminants (see [GKZ, page 445]) is the following: What can be said about the ideal JA? A reason for this question emerges, among other things, from results which show that information on the depth of JA and, more finely, on the primary decom...