نتایج جستجو برای: aptx gene
تعداد نتایج: 1141372 فیلتر نتایج به سال:
objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...
conclusions some results of the correlation coefficients are not the same with visualization. the reason may be due to the small number of data. materials and methods in the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as spearman’s rank correlation coefficient and blomqvist’s measure, and compared them with pearson’s correlation coefficie...
Aprataxin, defective in the neurodegenerative disorder ataxia oculomotor apraxia type 1, resolves abortive DNA ligation intermediates during DNA repair. Here, we demonstrate that aprataxin localizes at sites of DNA damage induced by high LET radiation and binds to mediator of DNA-damage checkpoint protein 1 (MDC1/NFBD1) through a phosphorylation-dependent interaction. This interaction is mediat...
ماکروفاژها از سلولهای مهم سیستم ایمنی در پاسخ به عوامل بیماریزای مختلف از جمله ویروس هرپس سیمپلکس یک 1- hsv0 هستند و عوامل موثر بر فعالیت آنها می توانند در سرنوشت بیماری موثر باشند. در این مطالعه اثر نوروپپتیدهای substance p(sp) وcalcitonin gene related-peptide (cgrp) که تحت شرایطی مثل استرس و التهاب از رشته های عصبی حسی آزاد می شوند و دارای گیرنده فعال بر روی ماکروفاژها می باشند ...
in view of the fundamental role of genetics in development of obesity, the present study aimed to investigate the single nucleotide polymorphism of some obesity-related genes among a subset of obese women living in tabriz, iran. for this purpose, 70 eligible obese women (aged 18-45 years) were genotyped for the uncoupling protein-1 (ucp-1) -3826a>g, ß3-adrenergic receptor (ß3adr) trp64arg, lept...
DNA3'pp5'G caps synthesized by the 3'-PO4/5'-OH ligase RtcB have a strong impact on enzymatic reactions at DNA 3'-OH ends. Aprataxin, an enzyme that repairs A5'pp5'DNA ends formed during abortive ligation by classic 3'-OH/5'-PO4 ligases, is also a DNA 3' de-capping enzyme, converting DNAppG to DNA3'p and GMP. By taking advantage of RtcB's ability to utilize certain GTP analogs to synthesize DNA...
Aprataxin is the causative gene product for early-onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia type 1 (EAOH/AOA1), the clinical symptoms of which are predominantly neurological. Although aprataxin has been suggested to be related to DNA single-strand break repair (SSBR), the physiological function of aprataxin remains to be elucidated. DNA single-str...
This paper is a pioneering attempt to utilize a Brownian motion (BM) process with drift to model the mobile radio channel under non-stationary conditions. It is assumed that the mobile station (MS) starts moving in a semi-random way, but subject to follow a given direction. This moving scenario is modelled by a BM process with drift (BMD). The starting point of the movement is a fixed point in ...
many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. early detection of mutation carriers in these genes, in turn, can play an import...
Letter Mutations in genes involved in singlestrand break repair (SSBR) have been linked to hereditary cerebellar ataxias. Notably, Ataxia-oculomotor apraxia 1 (AOA1 (MIM: 2 08 920)), Spinocerebellar ataxia with axonal neuropathy 1 (SCAN1 (MIM: 6 07 250)) and Ataxia-oculomotor apraxia 4 (AOA4 (MIM: 616267616267616267)) are associated with mutations in APTX (MIM: 606350), TDP1 (MIM: 607198) and P...
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