background : gastric cancer as the fourth most frequent malignancy worldwide was known to have the highest rate among cancer-related disorders in ardabil province. the product of tp53 gene regulated  the cell cycle process and acts as a tumor suppressor factor. the polymorphism p53 arg72pro (rs1042522) has been reported to be associated with many type of cancers.  the purpose of the present stu...

Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...

Abstract BACKGROUND In glioblastoma multiforme (GBM), bevacizumab increased progression-free survival but it has failed to improve overall (OS) in controlled trials. This study, therefore, aimed retrospectively analyze the polymorphisms of p53 codon 72 and clinical characteristics GBM specimens from Taiwanese patients. METHODS The 99 patients with treated at Taichung Veterans General Hospital T...

Cationic amino acid-based surfactants are known to interact with the lipid bilayer of microorganism resulting in cell death through a disruption membrane topology. To elucidate interaction cationic surfactant synthesized our lab, investigations involving Nα-benzoyl-arginine decyl amide (Bz-Arg-NHC10), and model membranes composed by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were done. ...

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [39]) are activated the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin may be used to label NTS1 0.1-0.3 3-5 nM concentrations...

Two experiments (Experiment 1 and 2) were conducted to evaluate growth performance, ascites mortality, and concentrations of plasma Arg, urea, and ornithine in male broilers raised in floor pens (2 x 4 factorial experiment, six pens for treatment) and exposed to cool temperatures averaging 16 C after 21 d of age. Broilers were fed low- or high-CP diets in both Experiments. In Experiment 1, Arg ...

Extracellular cues stimulate the Abl family nonreceptor tyrosine kinase Arg to promote actin-based cell edge protrusions. Several Arg-interacting proteins are potential links to the actin cytoskeleton, but exactly how Arg stimulates actin polymerization and cellular protrusion has not yet been fully elucidated. We used affinity purification to identify N-WASp as a novel binding partner of Arg. ...