We evaluated a family in which gynecomastia occurred in five males in two generations. In each affected subject, gynecomastia and male sexual maturation began at an early age. The ratio of the concentration of plasma estradiol-17#6 to that of plasma testosterone was elevated in each affected subject. In the three siblings with gynecomastia, the transfer constant of conversion of androstenedione...

Given the exceptionally high thermal stability of poly (para-phenylene) (PPP) among linear polyaromatics, it is expected that PPP fibers will have myriad applications. In this study, were obtained starting from enzymatic dihydroxylation/reduction benzene to 5,6-cis-dihydroxycyclohexa-1,3-diene, followed by esterification, polymerization, and aromatization. Polymer precursor was characterized in...

The isolation and cloning of a full-length cDNA insert complementary to mRNA encoding human aromatase system cytochrome P-450 is reported. The insert contains an open reading frame encoding a protein of 503 amino acids. This gene is clearly a member of the cytochrome P-450 gene superfamily, because the sequence contains regions of marked homology to those of other members, notably a putative me...

The aromatization of 2-octanol derived from castor oil as a byproduct in the formation of sebacic acid was investigated on various zeolite catalysts. Zn ion-exchanged MFI (ZSM-5) zeolites with small silica/alumina ratios and zinc contents of 0.5 to 2.0 wt. % were determined to exhibit good and stable activity for the reaction at 623 to 823 K. The yield of aromatics was 62% at 773 K and the spac...

Two distinct pathways for the formation of estriol in vitro have recently been described: C-16 hydroxylation of estradiol-17-P by human fetal liver and rat liver (1, 2), and aromatization of A5-androstene-3/?, 16a, 17&triol by human placenta (3). Although the formation in viva of estriol from estradioll and estrone is well known (4), the studies mentioned above present the first convincing data...

Phosphonylated azaheterocycles are an important class of compounds with high biological potential as conformationally restricted bioisosteres of amino acids. Therefore, it is of interest to synthesize conformationally constrained amino phosphonates. We wanted to investigate possible routes via ring opening of alpha-amino phosphonates with an oxanorbornene skeleton, as these can be synthesized w...

v2o5/sio2 nanoparticles was prepared via an one-pot sol gel method from vanadyl- acetylacetonate and tetraethylorthosilicate in refluxing meoh, followed by calcination at 700 °c for 2 hours. the resultant nanoparticles was characterized by means of scanning electron microscopy (sem), transmission electron microscopy (tem), x-ray diffraction (xrd), tga and ftir techniques. rapid and efficient ar...

This feature article describes the recent conceptual understanding of aromaticity and its contribution to thermodynamics in catalytic process involving dearomatization aromatization steps via metal-ligand cooperation.

Solid deposits from commercially available high-pressure diesel injectors (HPDI) were analyzed to study the solid deposition from diesel fuel during engine operation. The structural and chemical properties of injector deposits were compared to those formed from the thermal oxidative stressing of a diesel fuel range model compound, n-hexadecane at 160 degrees C and 450 psi for 2.5 h in a flow re...