Dr E J VELLA (Pathology Laboratory, Lakin Road, Warwick CV34 5BJ) and Dr C W EDWARDS (Departme9e of Pathology, East Birmingham Hospital, Birmingham B9 5ST) write: A 31 year old female drug misuser presented with pain in her right leg. She told the casualty doctor that a few hours previously she had crushed a few 10 mg tablets of temazepam, dissolved them in water, and injected the solution intr...

Responses of Surface Arteries and Blood Flow of Ischemic and Nonischemic Cerebral Cortex to Aminophylline, Ergotamine Tartrate, and Acetazolamide • In cats in which one middle cerebral artery was occluded, cortical blood flow (CBF) was measured and the superficial cortical microvasculature was observed bilaterally before and after the intravenous injection of a vasoactive drug. Aminophylline pr...

 We report a case of Nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. This case is unique because she developed compartment syndrome in her left calf far from her injection site. Her toe’s tips gangrened in the course of her ailment. We hypothesized that the compartment syndrome might be produced by a probable intra-arteri...

Arterial drug concentration distribution determines local toxicity. The safety issues dealt with Drug-Eluting Stents (DESs) reveal the needs for investigation about the effective factors contributing to fluctuations in arterial drug uptake. The current study focused on the importance of hypertension as an important and controversial risk factor among researchers on the efficacy of Heparin-Eluti...

There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipoph...

Introduction This paper proposes the concept of autonomous drug-encapsulated nanoparticle (ADENP) as a novel non-invasive approach to prevent atherosclerosis. ADENP consists of three simple units of sensor, controller (computing), and actuator. The hardware complexity of ADENP is much lower than most of the nanorobots, while the performance is maintained by the synergism in the swarm architectu...