Arteriosclerosis Obliteran (ASO) is a local manifestation of systemic arteriosclerosis in the lower extremity arteries. ASO chronic progressive disease caused by arteriosclerosis, such as intimal thickening, lumen stenosis or occlusion blood supply arteries limbs, insufficient diseased and clinical manifestations intermittent claudication, decreased skin temperature, pain, even ulceration necro...

The systematic search for the nephritogenic antigen in Group A streptococcus started more than 40 years ago with the evaluation of the M protein (1–4). The spotlight moved slowly away from M protein because the increasing number of nephritogenic M types (streptococci isolated from patients with nephritis) contrasted with the notion of a single nephritogen that would confer long-lasting immunity...

Background Banding of the pulmonary artery to induce left ventricular (LV) hypertrophy followed by arterial switch operation (ASO) within 2 weeks has been performed when a primary ASO was considered high risk because of inadequate LV hypertrophy. Methods and Results Potential adverse myocardial effects of the two-stage procedure were examined by comparing outcome in 18 patients after a rapid tw...

The title compound, silver disodium trimolybdenum(VI) nonaoxide arsenate, AgNa(2)Mo(3)O(9)AsO(4), was prepared by a solid-state reaction at 808 K. The structure consists of an infinite (Mo(3)AsO(13))(n) ribbon, parallel to the c axis, composed of AsO(4) tetra-hedra and MoO(6) octa-hedra sharing edges and corners. The Na and Ag ions partially occupy several independent close positions, with vari...

Results A total of 163 ASO procedures of all types were identified. The diagnoses were; TGA/IVA 88, TGA/VSD 53, TGA/ arch 5, TGA/VSD/arch 4, Taussig Bing 10, Taussig Bing/ arch 9, for a total of 169, ten patients underwent a staged repair in preparation for ASO of which 4 died. One died before intervention, one did not undergo ASO operation at our institution. Total mortality for all ASO proced...

Arterial switch operation (ASO) is a complex neonatal in which transfer of the coronary arteries origins key to success. Coronary events after successful ASO are not uncommon. We describe rare case child who underwent an period with one (LAD) described as atretic left place. At age seven, he developed myocardial ischemia due retrograde flow steal phenomenon from LAD into pulmonary artery. The p...

Following recent advances in technology for hemodialysis, the number of patients with chronic renal failure receiving long-term hemodialysis remains to be increasing. Arteriosclerosis obliterans (ASO) has attracted attention as a significant clinical problem in hemodialysis patients. Although several epidemiological studies on the development of ASO in hemodialysis patients are reported, there ...

While studying transgenic mice that overexpress human wildtype alpha-synuclein (Thy1-ASO, ASO) for typical brain alpha-synucleinopathy and central nervous system neuropathology, we observed progressive functional changes in the gastrointestinal and other peripheral organs. A more systematic study revealed that the gastrointestinal tract in ASO mice showed severe distension and blockage of the l...

PURPOSE A low ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) has been associated with coronary artery disease. We retrospectively examined serum concentrations of polyunsaturated fatty acids in patients with arteriosclerosis obliterans (ASO) and in non-atherosclerotic patients. METHODS From April 2011 to March 2012, serum EPA/AA was retrospectively examined in 33 consecutiv...

Approaches that improve upon the pharmacokinetic and pharmacodynamic properties of singlestrand antisense oligonucleotides are an active research topic. Antisense oligonucleotide phosphorothioates (ASOs) are highly protein bound. Therefore, it is likely that they traffic into and through cells via a protein to protein shuttling mechanism driven by binding affinity gradients.1 The ASO binding ev...