Ceftriaxone is a third generation cephalosporin group of broad spectrum anti-biotic. It active against the gram positive and gram negative organisms. Which is commonly used antibiotic in patients with various infections like respiratory tract infection, urinary tract infection, enteric fever and meningitis. Hypersensitive reactions subsequent ceftriaxone therapy is unusual but is potentially li...

Hypersensitivities induced by isopropylantipyrine (IPA), a pyrazolone derivative within the wider family of non-steroidal anti-inflammatory drugs (NSAIDs), are rarely reported. We characterized the clinical features of 12 patients with IPA-induced hypersensitivity. Twelve patients with immediate hypersensitivity to IPA were enrolled and classified into two groups: group I, consisting of eight p...

Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with type I hypersensitivity, including cutaneous manifestations (e.g., urticaria and angioedema), respiratory manifestations (rhinitis, nasal polyposis, asthma), and anaphylaxis. To assess the sensitivity/specificity of in vitro tests for verifying the causative/tolerant drugs and crossreactivity of different NSAIDs, we used three a...

Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. Effect of endobronchial aspirin challenge on inflammatory cells in bronchial biopsy samples from aspirin-sensitive asthmatic subjects. Expression of interleukin-5 and granulocyte-macrophage ...

Aspirin-exacerbated respiratory disease (AERD) remains widely underdiagnosed in asthmatics, primarily due to insufficient awareness of the relationship between aspirin ingestion and asthma exacerbation. The identification of aspirin hypersensitivity is therefore essential to avoid serious aspirin complications. The goal of the study was to develop plasma biomarkers to predict AERD. We identifie...

BACKGROUND A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). OBJECTIVE To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. METHODS A cross sectional multicenter study was done...