Exercise tolerance and possible limitation in work capacity of asthmatic children is still a matter of debate. The aim of this study was to compare ventilation and gas exchange response to exercise of asthmatic children with that of healthy controls. Exercise performance was evaluated in 80 children with mild-to-moderate asthma, aged 7-15 yrs, and in 80 healthy controls matched for age, height,...

Asthma is a serious global health risk characterized by chronic airway inflammation of lungs with infiltration inflammatory cells, enhanced mucus secretion and narrowing airways that leads to poor respiratory functions. The clinical symptoms asthma includes recurrent episodes cough, shortness breath, wheezing chest tightness. One the pathophysiology was mediated overproduction pro-inflammatory ...

BACKGROUND Mast cell microlocalisation within the airway smooth muscle (ASM) bundle is an important determinant of the asthmatic phenotype. We hypothesised that mast cells migrate towards ASM in response to ASM derived chemokines. METHODS Primary ASM cultures from subjects with and without asthma were stimulated with interleukin (IL)-1beta, IL-4, and IL-13 alone and in combination. Mast cell ...

Asthma, a chronic inflammatory airway disease, is typified by high levels of TH2-cytokines and excessive generation of reactive nitrogen and oxygen species, which contribute to bronchial epithelial injury and airway remodeling. While immune function plays a major role in the pathogenesis of the disease, accumulating evidence suggests that altered cellular metabolism is a key determinant in the ...

Respiratory activity may have an influence on craniofacial development and interact with genetic and environmental factors. It has been suggested that certain medical conditions such as asthma have an influence on face shape. The aim of the study is to investigate whether facial shape is different in individuals diagnosed as having asthma compared with controls. Study design included observatio...

BACKGROUND there is little information available on physical activity (PA) patterns and the psychosocial determinants of PA in older adults with asthma. OBJECTIVE to quantify the prevalence of PA in older asthmatics and to explore the potential psychosocial determinants of PA in this population. STUDY DESIGN AND SETTING cross-sectional data available from the Canadian Community Health Surve...

BACKGROUND Asthma is a chronic airway disease which is characterized by oxidant antioxidant imbalance with the generation of oxidative stress related mediators. AIM The study aimed to evaluate the role of asymmetric dimethylarginine, and malondialdehyde as oxidant markers and serum paraoxonase activity as an antioxidant marker in asthma, and to determine their relationship to the asthma sever...

Peripheral blood mononuclear cells (PBMC) were isolated from seven normal subjects, eight asthmatic subjects clinically sensitive to corticosteroids (CS), and eight asthmatic subjects clinically resistant to corticosteroids (CR). PBMC were cultured at 37 degrees C for 24 h in the absence or presence of 10(-16) to 10(-4) M hydrocortisone. Calcium ionophore (A23187)-activated neutrophils (PMN) pr...

Asthma is a non communicable obstructive lung disease. It condition in which person's airways become inflamed, narrow, swell, and produce extra mucus, making breathing difficult. After being diagnosed with asthma patients not only suffer from physical symptoms but also mental disorders such as prolonged stress, anxiety disorders, depression, PTSD (Post-traumatic stress disorders), fear panic al...