BACKGROUND UCN-01, a Chk1 inhibitor, abrogates S and G(2) arrest and enhances cancer cell killing by DNA-damaging drugs in preclinical models. UCN-01 avidly binds alpha1-acid glycoprotein in plasma; whether sufficient drug concentrations are achieved in human tumors is unknown. A phase I trial tested the hypothesis that UCN-01 abrogates cisplatin-induced cell cycle arrest (in tumors) at tolerab...

in this study, antimicrobial activity of chitosan and whey protein isolate edible films incorporated with different concentrations of zataria multiflora boiss essential oil ;zeo (1%, 2%, 3% and 4% v/v) and zataria multiflora boiss essential oil nanoliposome (0, 1, 2, 3 and 4%) against  listeria monocytogenes (atcc 19118), bacillus cereus (atcc 11778), staphylococcus aureus (atcc 65138), escheri...

The role of the sensitivity of bone marrow cells to, and the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF) on the rhythm of leukocyte-increasing effect was investigated in ICR male mice housed under a standardized light-dark cycle (lights on at 0700, off at 1900). A significant circadian rhythm was demonstrated for leukocyte counts at 24 hr after G-CSF (250 microg/kg, s.c.) ...

DNA-damaging agents arrest cell cycle progression at either G1 or G2. A variety of agents such as caffeine have been shown to abrogate the DNA damage-dependent G2 checkpoint and enhance cytotoxicity. Unfortunately, this strategy has not enhanced therapeutic activity because adequate concentrations of these modulators are not tolerated in vivo. Here, using Chinese hamster ovary cell lines, we sh...

zinc sulphate and boric acid ophthalmic preparations, containing benzalkonium chloride as preservative, have been investigated against gram-negative and positive bacteria. viability of bacteria was found after 7 days, although it was completely suppressed after 24 hours of inoculation. zinc sulphate generally increases the antimicrobial activity of benzalkonium chloride, whereas boric acid or i...