نتایج جستجو برای: atc 40
تعداد نتایج: 334885 فیلتر نتایج به سال:
NGS based identification of mutational hotspots for targeted therapy in anaplastic thyroid carcinoma
CONTEXT Anaplastic thyroid carcinoma (ATC) represents one of the most aggressive carcinomas with no consistent survival benefit when treated with conventional radiochemotherapy. Approaches targeting "oncogene addiction" of ATC are increasingly explored and first promising results have been reported in single case studies. OBJECTIVE To determine the prevalence of mutations in known thyroid onc...
Air traffic control (ATC) is based on voice communication between pilots and controllers and uses a highly task and domain specific language. Due to this very reason, spoken language technologies for ATC require domain-specific corpora, of which only few exist to this day. The ATCOSIM Air Traffic Control Simulation Speech corpus is a speech database of non-prompted and clean ATC operator speech...
Anaplastic thyroid carcinoma (ATC) is a frequently lethal malignancy that is often unresponsive to available therapeutic strategies. The tumorigenesis of ATC and its relationship to the widely prevalent well-differentiated thyroid carcinomas are unclear. We have analyzed 22 cases of ATC as well as 4 established ATC cell lines using whole-exome sequencing. A total of 2674 somatic mutations (121/...
Anaplastic thyroid carcinoma (ATC) although rare is the most lethal form of thyroid cancer. The mortality rate for ATC is very high, with a median survival time of only 5 months; the survival rate at 1 year after diagnosis is <20%. Management of ATC is extremely difficult and rife with uncertainties. Herein, we describe a 75-year-old woman who presented with ATC and was successfully treated usi...
In this paper, an optimal power flow based approach has been applied for multi-transactions deregulated environment for ATC determination with SVC and STATCOM. The main contribution of the paper is (i) OPF based approach for evaluation of ATC with multi-transactions, (ii) ATC enhancement with FACTS devices viz. SVC and STATCOM for intact and line contingency cases, (iii) Impact of ZIP load on A...
Recent increase in air traffic demands makes the role of Air Traffic Control (ATC), which supports safety and efficiency of aviation, more important than ever. As aviation technologies have progressed, automation and computer supports are being introduced in cockpits, but ATC still heavily relies on human expertise of Air Traffic Control Officers (ATCOs). It is therefore necessary to understand...
Kevin M. Guskiewicz, PhD, ATC, FACSM; Scott L. Bruce, MS, ATC; Robert C. Cantu, MD, FACSM; Michael S. Ferrara, PhD, ATC; James P. Kelly, MD; Michael McCrea, PhD; Margot Putukian, MD, FACSM; and Tamara C. Valovich McLeod, PhD, ATC, CSCS, contributed to conception and design, acquisition and analysis and interpretation of the data; and drafting, critical revision, and final approval of the articl...
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and chemoresistant cancers. The serine/threonine kinase Polo-like kinase 1 (PLK1), a key regulator of multiple steps during mitotic progression, is highly expressed in ATC. Here, we used the BI 2536 PLK1 inhibitor on ATC and nontransformed thyroid follicular cell lines. Our data show that ATC cells are addicted to high levels of P...
Currently, Air Traffic Control (ATC) systems are reliable with automation supports, however, the increased traffic density and complex air traffic situations bring new challenges to ATC systems and air-traffic controllers (ATCOs). We conduct an experiment to evaluate the current ATC system and test conflict resolution automation and tactile user interface to be the inputs of the future ATC syst...
BACKGROUND AND RATIONALE Anaplastic thyroid cancer (ATC) is characterized by pleomorphic cells, has a poor prognosis, is highly devastating disease, and is not curable. No reliable biomarkers of metastatic potential, helpful for early diagnosis of ATC and therapeutic response have been found yet. Thrombospondin-1 (TSP-1) plays a fundamental role in cancer progression by regulating cell stromal ...
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