With the aim of establishing whether a genetically reduced capability of producing apolipoprotein E (apo E) can affect atherogenesis, we have compared the consequences of dietary stress on normal mice and on mice heterozygous or homozygous for a disrupted apo E gene. A dramatically accelerated development of lesions occurred in the vasculature of the homozygous mutants as a result of feeding an...

With the aim of establishing whether a genetically reduced capability of producing apolipoprotein E (apo E) can affect atherogenesis, we have compared the consequences of dietary stress on normal mice and on mice heterozygous or homozygous for a disrupted apo E gene. A dramatically accelerated development of lesions occurred in the vasculature of the homozygous mutants as a result of feeding an...

BACKGROUND Sesamin, a major lignan from sesame seeds has been associated with cholesterol reduction in previous reports, but recent studies suggested differences in the response to sesamin intake depending on the model studied as well as the nature of the sesamin preparation used. AIM The effect of pure sesamin epimer on serum lipids was studied in hypercholesterolemic LDL receptor-knockout m...

The study was aimed to characterize the probiotic properties of a Pediococcus pentosaceus strain, KID7, by in vitro and in vivo studies. The strain possessed tolerance to oro-gastrointestinal transit, adherence to the Caco-2 cell line, and antimicrobial activity. KID7 exhibited bile salt hydrolase activity and cholesterol-lowering activity, in vitro. In vivo cholesterol-lowering activity of KID...

Soy protein diets lower plasma cholesterol in hyperlipoproteinemic human subjects, as well as in animal models. We fed 7-wk-old male obese (fa/fa) and lean Zucker rats a modified AIN-76 diet (20 g protein/kg diet) containing casein (C), low isoflavone soy protein (38 mg isoflavones/kg diet; LI), or high isoflavone soy protein (578 mg isoflavones/kg diet; HI) for 70 d. In obese rats, plasma tota...

The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts leaves Ougeinia oojeinensis (Roxb.) belonging family Fabaceae. soxhlation method employed produce extracts. Wistar rats were subjected a high-fat diet for 40 days induce obesity. Along with diet, standard drug Orlistat 50 mg/kg various O. at 100 200 administered days. key...

• During the course of our studies on the role of hormones in atherosclerosis, we have become increasingly aware of the importance of the protein level in the diet upon the action of hormones." In the present study, therefore, the lipid and atherogenic responses to the administration of an anabolic hormone, testosterone propionate, and a catabolic hormone, hydrocortisone (compound F), were anal...

Abstract Background Circadian disruption is often associated with aggravation of atherosclerosis; however, the pathophysiological mechanisms underlying atherogenic initiation in normolipidemic diet remains unclear. Most studies done for understanding circadian induced atherosclerosis have been carried out murine model hyperlipidemia atherosclerosis. The present study investigates pro-atherogeni...

Over the centuries plants have been effectively used as a potent source of traditional medicine. Present experiment was aimed to evaluate the hypocholesterolemic and anti-atherogenic effect of feeding Terminalia chebula powder (TCP) in rabbits. A total of (n=20) rabbits were assigned to four treatment groups with n=5 animals in each group. Experimental treatments received Normal Saline (NS); T....

SCOPE Traditional Mediterranean diet (TMD) protects against cardiovascular disease through several mechanisms such as decreasing LDL cholesterol levels. However, evidence regarding TMD effects on LDL atherogenic traits (resistance against oxidation, size, composition, cytotoxicity) is scarce. METHODS AND RESULTS We assessed the effects of a 1-year intervention with a TMD on LDL atherogenic tr...