Atherosclerosis represents a heterogenous group of pathological phenomena involving degenerative, inflammatory and proliferative processes which produce lesions containing mainly cellular material, lipid, collagen and calcium. Despite the varying pathological forms, the clinical sequelae of atherosclerosis are well defined and affect coronary, cerebrovascular and peripheral arteries. The Office...

Background—Rosiglitazone has several properties that may affect progression of atherosclerosis. The Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in Diabetes Patients With Cardiovascular History (APPROACH) study was undertaken to determine the effect of the thiazolidinedione rosiglitazone on coronary atherosclerosis as assessed by intravascular ultrasound compa...

OBJECTIVE Although statins can induce coronary atheroma regression, this benefit has yet to be demonstrated in diabetic individuals. We tested the hypothesis that high-intensity statin therapy may promote coronary atheroma regression in patients with diabetes. RESEARCH DESIGN AND METHODS The Study of Coronary Atheroma by Intravascular Ultrasound: Effect of Rosuvastatin Versus Atorvastatin (SA...

Many clinical studies have shown an increased insulin response to oral glucose in patients with ischemia of the heart, lower limbs, or brain. Hyperinsulinemia also occurs in patients with angiographically proved atherosclerosis without ischemia and thus appears to be related to arterial disease and not to be a nonspecific response to tissue injury. Fasting insulin levels and insulin responses t...

Atherosclerosis represents a heterogenous group of pathological phenomena involving degenerative, inflammatory and proliferative processes which produce lesions containing mainly cellular material, lipid, collagen and calcium. Despite the varying pathological forms, the clinical sequelae of atherosclerosis are well defined and affect coronary, cerebrovascular and peripheral arteries. The Office...