BACKGROUND The evidence for systemic treatments for severe childhood eczema is limited and largely based on extrapolation of data from adult studies. Current therapies are often immunosuppressant and may be associated with both short- and long-term side effects. There is increasing in vitro and murine-model evidence for the role of IgE in the immunopathogenesis of atopic eczema. The aim of the ...

Eczema is a chronic relapsing atopic dermatitis (AD) associated with pruritus, sleep disturbance and poor quality of life of the patient. Treatment of eczema includes use of emollient, topical and systemic antimicrobial agents, corticosteroid or immunomodulating agents. Many patients also seek alternative treatments such as dietary avoidance, supplementation or both. This article reviews the ba...

asthma and allergic diseases present a major health burden. information on the prevalence of these diseases indicates that these diseases are increasing in various parts of the world. it was hoped that this study would be helpful to health system policy-makers in planning allergy prevention programs in the region.the prevalence of asthma and allergic diseases and relation between the various ri...

many patients with atopic eczema (ae) would “march” to develop allergic rhinitis (ar) and asthma. physicians, patients and their families often do not appreciate the significance of these diseases as co-morbidities of atopy. the aim of this study was to evaluate the prevalence and severity of airway atopies in patients with ae. ar and asthma severity were assessed in consecutive ae patients see...

Current clinical research in eczema (atopic dermatitis) is hampered by a profusion of outcome measures, most of which have not been developed or tested adequately. The first Harmonising Outcome Measures for Eczema meeting (HOME 1) was an exploratory meeting to determine whether there was sufficient interest and enthusiasm in the international scientific community to form a collaborative group t...

Itch represents a leading symptom in dermatological practice with many psychophysiological aspects. Instruments for qualitative registration of these central nervous factors and evaluation of therapeutic measures are still missing. We analyzed in detail the subjective itch sensation in 108 patients with acute atopic eczema with a new questionnaire developed in analogy to the McGill pain questio...

PURPOSE A comprehensive and representative nationwide general practice database was explored to study associations between atopic disorders and prescribed medication in children. METHOD All children aged 0-18 years listed in the NIVEL Primary Care Database in 2014 were selected. Atopic children with atopic eczema, asthma and allergic rhinitis (AR) were matched with controls (not diagnosed wit...

Background. Systematic international comparisons of the prevalences of asthma and other allergic disorders in children are needed for better understanding of their global epidemiology, to generate new hypotheses, and to assess existing hypotheses of possible causes. We investigated worldwide prevalence of asthma, allergic rhinoconjunctivitis, and atopic eczema. Methods. We studied 463 801 child...

AIMS To establish whether development of eczema is influenced by feeding practices in preterm infants, while taking account of confounding factors. METHODS Data were assembled from 257 infants born prematurely and studied to 12 months post-term. Logistic regression analysis was performed to establish the association between feeding practices and eczema, allowing for potential confounding fact...

BACKGROUND While in developed countries the prevalence of allergic diseases is rising, inflammatory diseases are relatively uncommon in rural developing areas. High prevalence rates of helminth and protozoan infections are commonly found in children living in rural settings and several studies suggest an inverse association between helminth infections and allergies. No studies investigating the...