Three sensitive methods were developed for simultaneous determination of Ezetimibe (EZB) and Atorvastatin calcium (ATVC) in binary mixtures. First derivative (D(1)) spectrophotometry was employed for simultaneous determination of EZB (223.8 nm) and ATVC (233.0 nm) with a mean percentage recovery of 100.23 ± 1.62 and 99.58 ± 0.84, respectively. Linearity ranges were 10.00-30.00 μg mL(-1) and 10....

OBJECTIVE To compare adherence with statin therapy in patients switching to single-pill amlodipine besylate/atorvastatin calcium with patients adding a separate statin to their amlodipine regimen. METHODS We identified hypertensive patients prescribed amlodipine who switched to amlodipine/atorvastatin (switch) or added a statin to their amlodipine regimen (add-on) from July 2004 to June 2007....

BACKGROUND Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are widely used for the treatment of hypercholesterolemia and coronary heart disease and for the prevention of stroke. There have been various adverse effects, most commonly affecting muscle and ranging from myalgia to rhabdomyolysis. These adverse effects may be due to a coenzyme Q(10) (CoQ(10)) deficiency because ...

In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were performed to select a suitable combination of oil, surfactant, and cosurfactant. A D-optimal mixture design was used to optimize the conce...

OBJECTIVE The aim of this paper is to evaluate the effect of atorvastatin on bone mineral density in patients with acute ischemic heart disease. MATERIAL AND METHODS Eighty-three patients (52 male and 31 female) with acute coronary syndrome were studied. They received treatment with atorvastatin using low doses (20 mg) and high doses (40 mg-80 mg). Initial and final cholesterol, triglyceride,...

In the title compound, [Cu(2)(C(12)H(8)N(3)O(2))(2)(C(6)H(8)O(4))(H(2)O)(2)]·3H(2)O, both crystallographically independent Cu atoms are in similar distorted square-pyramidal coordination environments. The dinuclear complex mol-ecules are assembled into one-dimensional supra-molecular chains extending in the [100] direction by hydrogen bonds. Inter-chain hydrogen bonds further link these chains ...

*Department of Pharmaceutical Chemistry, M.S.Ramaiah College of Pharmacy, Bangalore 560054, Karnataka India,1Department of pharmacy, Annamalai University, Annamalai Nagar-608002, Chidambaram, Tamil Nadu, India,2Department of Pharmacognosy, M.S.Ramaiah College of Pharmacy, Bangalore 560054, Karnataka India,3School of Chemical and Biotechnology, SASTRA University, Thanjavur 613402, Tamil Nadu, In...

BACKGROUND Currently, the discovery of effective chemotherapeutic agents poses a major challenge to the field of cancer biology. The present study focuses on enhancing the therapeutic and anti cancer properties of atorvastatin calcium loaded BSA (ATV-BSA) nanoparticles in vitro. METHODOLOGY/RESULTS BSA-ATV nanoparticles were prepared using desolvation technique. The process parameters were op...

OBJECTIVES This study sought to evaluate the effect of intensive and moderate statin therapy on epicardial adipose tissue (EAT). BACKGROUND EAT has been associated with coronary artery disease severity and outcome. It is currently unknown whether EAT volume changes over time when patients are exposed to statin therapy. METHODS Subanalysis of a randomized study of atorvastatin 80 mg/day vers...