Background Chlorpromazine (CPZ), an antipsychotic drug, is associated with increased risk of sexual dysfunction through increasing prolactin levels. The current study evaluates the effect of CPZ-induced hyperprolactinemia on ovarian follicular growth, gonadotropins, and alteration of ovarian source hormones. MaterialsAndMethods In this experimental study, animals were divided into four groups, ...

Background: Bisphenol A (BPA), an estrogenic environmental contaminant is also known for oxidative stressinducing effect. The aim of this study was to investigate the effect of vitamin C as an antioxidant on the ovary tissue in adult rats treated with BPA. Materials and Methods: Adult female rats (200 ±20 g) were divided into 4 groups (n=6):control, bisphenol A (60μg/Kg/day) , vitamin C (150 mg...

There is currently much interest in assisted reproduction techniques in the horse, however, many aspects of oocyte maturation, fertilization, and embryo development in the horse differ from those in other species. Because of the close attachment of the equine oocyte to the follicle wall, scraping of the follicle is the most effective method for oocyte recovery. A notable feature of equine oocyt...

BACKGROUND AND PURPOSE Transverse sinus thrombosis can have nonspecific clinical and radiographic signs. We hypothesized that the novel "sigmoid notch sign" (on head CT) can help differentiate transverse sinus thrombosis from a congenitally atretic sinus among individuals with absent signal in 1 transverse sinus by MR venography. METHODS We retrospectively evaluated 53 subjects with a unilate...

Abstract Study question Can we obtain secondary follicles from cultured cryopreserved-thawed human cortical tissue? Summary answer We obtained a comparable percentage of after culture tissue to that reported fresh tissue. What is known already The complete in vitro maturation oocytes starting primary (present unilaminar follicles) until mature MII has been achieved previously by two different m...

The aim of this study was to explore the real time changes in the vascularity of growing superovulated follicles and to establish whether the blood flow of growing follicles can affect superovulation variability. Eight Holstein-Freisian cows received PGF2α 10 days after spontaneous ovulation. After 36 hours, all follicles larger than 5 mm were aspirated at day 0 (D0). Animals were given 28 Armo...

To assess the effects of a gonadotropin-releasing hormone agonist, [D-Leu6,des-Gly10] luteinizing hormone-releasing hormone ethylamide, in ameliorating the damage caused by ionizing radiation, gonadotropin-releasing hormone agonist was administered to rats from day 22 to 37 of age in doses of 0.1, 0.4, and 1.0 microgram/day or vehicle and the rats were sacrificed on day 44 of age. There were no...

Ski protein is implicated in proliferation/differentiation in a variety of cells. We had previously reported that Ski protein is present in granulosa cells of atretic follicles, but not in preovulatory follicles, suggesting that Ski has a role in apoptosis of granulosa cells. The alternative fate of granulosa cells other than apoptosis is to differentiate to luteal cells; however, it is unknown...

We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model ovarian damage induced by cyclophosphamide. A total 44 female rats with premature insufficiency cyclophosphamide were randomly divided into two groups (an group and control group); 22 normal without also included as third group. The was treated LIPUS, while other received same treatment but any power o...