Muscle atrophy following injury can be alleviated by periodic, lateral muscle compression via massage therapy or periodically actuated magnetically hydrogel implants that simulate massage. Although contraction parallel to a muscle’s contractile axis is well known superior such for promoting strengthening in both athletic training and mechanobiology, it not whether this the case preventing disus...

Multiple sclerosis (MS) is a chronic immune mediated, inl ammatory, demyelinating disease of the central nervous system (1). New magnetic resonance imaging (MRI) techniques have shown microstructural damage either at white matter or gray matter, proven to be of histopathologic nature (2). Inl ammation in MS has been proven, especially in deep white matter, gray matter and interstitial area, so ...

PURPOSE To report the MR and CT findings in a hereditary disease, infantile-onset spinocerebellar ataxia (IOSCA). METHODS We studied the brains of 17 patients with infantile-onset spinocerebellar ataxia with CT and/or MR to determine the presence of cerebellar and brain stem atrophy and parenchymal lesions. RESULTS Cerebellar cortical atrophy was seen in 13 patients. The degree of atrophy c...

BACKGROUND Atrophy of rotator cuff muscles has been considered an irreversible phenomenon. The purpose of this study is to evaluate whether atrophy is truly irreversible after rotator cuff repair. METHODS We measured supraspinatus muscle atrophy of 191 patients with full-thickness rotator cuff tears on preoperative magnetic resonance imaging and postoperative multidetector computed tomography...

Powers SK, Wiggs MP, Duarte JA, Zergeroglu AM, Demirel HA. Mitochondrial signaling contributes to disuse muscle atrophy. Am J Physiol Endocrinol Metab 303: E31–E39, 2012. First published March 6, 2012; doi:10.1152/ajpendo.00609.2011.—It is well established that long durations of bed rest, limb immobilization, or reduced activity in respiratory muscles during mechanical ventilation results in sk...

BACKGROUND Age-related brain atrophy has been represented by simple 1-dimensional (1-D) measurements on computed tomography (CT) for several decades and, more recently, with 3-dimensional (3-D) analysis, using brain volume (BV) and cerebrospinal fluid volume (CSFV). We aimed to show that simple 1-D measurements would be associated with 3-D values of age-related atrophy and that they would be re...

BACKGROUND Early stage patients with Parkinson's disease (PD) show cognitive impairment in frontal lobe functions and memory tests. Hippocampal atrophy is seen in medicated patients with advanced PD. OBJECTIVES To examine whether prefrontal or hippocampal atrophy are already present in early stage PD, and whether such atrophy is associated with cognitive impairment. METHODS Twenty non-medic...

To our knowledge, this is the largest study evaluating relationships between 3T Magnetic Resonance Imaging (MRI) and P300 and memory/cognitive tests in the literature. The 3T MRI using NeuroQuant has an increased resolution 15 times that of 1.5T MRI. Utilizing NeuroQuant 3T MRI as a diagnostic tool in primary care, subjects (N=169; 19-90 years) displayed increased areas of anatomical atrophy: 3...

Multiple system atrophy (MSA) is a neurodegenerative disease belonging to group of synucleinopathies and characterized by significant autonomic failure, parkinsonian syndrome, cerebellar signs. Diagnostic criteria used currently were updated in 2022. While the clinical method neuroimaging are typically diagnostic MSA, new modalities emerging. Novel candidate biomarkers being intensively thoroug...