We report an 82-year-old woman who underwent fixation with a long-spanning cable-plate for a bisphosphonate-induced Vancouver B1 periprosthetic femoral fracture. Non-union and breakage of the plate occurred at 16 months and necessitated revision surgery using a long-stem femoral prosthesis augmented with a cable-plate construct. Bone union was achieved eventually after 10 months.

BACKGROUND Fracture of the penis is an uncommon injury presenting to the emergency department (ED). Personal embarrassment and social scenarios associated with this condition may result in underreporting. Patients often delay seeking medical attention, and even when they do, as in our case report, they may withhold the condition for a significant time. ED physicians need to be aware of the soci...

This type of fracture is related to the use of bisphosphonates (BFN), the first report was published in 2005 by Odvina [2]. In 2013 the American Society for Bone and Mineral Research (ASBMR) described the criteria for FFA diagnosis. These criteria were classified as major and minor (Table 1) [1], at least 4 major criteria are needed for FFA diagnosis; juveniles are not needed but are usually pr...

INTRODUCTION Delayedand nonunion are common complications that occur after 510% of fractures. Iliac crest bone grafting, the current gold standard of treatment for nonunion, provides a limited source of grafting material and is associated with persistent donor site pain. Hernigou et al. reported the use of percutaneous injection of concentrated autologous bone marrow to treat nonunions with fra...

Bisphosphonates are a class of drugs that prevent bone loss by decreasing bone resorption. They represent a major treatment for osteoporosis and other metabolic bone diseases. Recent reports suggest that a potential complication of long-term bisphosphonate therapy may be atypical insufficiency fractures of the femur. Concern exists about delayed union after fracture stabilization in patients ta...

BACKGROUND Antipsychotics are frequently and increasingly prescribed to treat the behavioural symptoms associated with dementia despite their modest efficacy. Evidence regarding the potential adverse events of antipsychotics is limited and little is known about the longer-term safety of these medicines in the elderly. The aim of this review was to determine the impact of the choice of observati...

A case of a 62-year-old woman with breast cancer who developed an atypical femoral fracture during denosumab therapy for bone metastasis is reported. About 8.5 years before the fracture, she was diagnosed with breast cancer with liver and bone metastases and started receiving chemotherapy. Three and a half years later, zoledronic acid (40 mg every 4 weeks) was added, which was continued for 2 y...

A typical complication of ankylosing spondylitis with an atypical patient history is reported and the topic is discussed. The diagnosis of a spinal fracture may be difficult in a "bamboo spine".

Osteoporosis is responsible for a significant burden both individually and socially, but is readily treated with antiresorptive agents and mineral supplementation. However, long-term usage of these agents, notably bisphosphonates, is rarely associated with atypical fractures. Denosumab is a monoclonal antibody that reduces osteoclast activity and thus increases bone mineral density. In this cas...