OBJECTIVES Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer's disease (AD). This research aimed to investigate the...

Examination of the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, showed that it contained naringin (NGIN; 44.02 ± 0.491 mg/g), narirutin (NRTN; 4.46 ± 0.0563 mg/g), auraptene (AUR; 4.07 ± 0.033 mg/g), and 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF; 0.27 ± 0.0039 mg/g). When this dried peel powder was orally preadministered at the dose of 1.2 or 2.4 g/kg/day...

Correspondence and reprint request: Dr. Amirhossein Sahebkar, Pharm.D. Biotechnology Research Center, School of Pharmacy, P.O.Box: 91775-1365 Cardiovascular Research Center Avicenna Research Institute Mashhad University of Medical Sciences Mashhad, Iran E-mail: [email protected] Manuscript received: March 07, 2011. Manuscript accepted: June 24, 2011. October-December, Vol. 10 No.4, 2011:...