abstract background patients who are to receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate, and which drug doses should be modified. following therapy abnormalities of liver function tests may be due to the therapy rather than to progressive disease, and this distinction is of critical importance. toxicity such as...

A 5 1/2-year-old girl, with a life-long history of recurrent staphylococcal infections and eczematous dermatitis had a defect in polymorphonuclear leucocyte chemotaxis and phagocytosis in autologous serum, a high serum IgE level, and a disturbed T cell function. Levamisole improved all the immunological abnormalities and there was a dramatic clinical improvement. Discontinuation of therapy with...

Objective We test the hypothesis that aspartate aminotransferase (AST) may be associated inversely with serum triglycerides (TG) and positively with high density lipoprotein (HDL) cholesterol in young athletes because athletes have larger amounts of muscle mass. Research design and methods Pearson's correlation coefficients were calculated between serum AST and alanine aminotransferase (ALT) ...

PURPOSE To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic tissue was taken for histological assessment and biochemical assays. Oxidative stress parameters malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutas...

Two cases of GVHD with severe dry eyes are reported where conventional therapy failed to control ocular signs and symptoms. Autologous serum tears, however, resulted in a beneficial clinical effect with marked attenuation of the symptoms. This therapy proved to be safe during 10 months of treatment. Bone Marrow Transplantation (2000) 25, 1101–1103.

Background: There is substantial evidence that environmental factors cause or accelerate the onset of malignancy. Environmental factors, due to the presence of many pollutants and carcinogenic agents, alter cellular growth, which leads to biochemical changes in the blood. Materials and Methods: In the present study, we estimated serum pseudocholinesterase (PCHE), serum aspartate transaminase (A...

Background: Isotretinoin is a synthetic vitamin A analogue that is used to treat severe acne and other dermatologic diseases. However there are some concerns about this drug regarding the adverse effects. Aim: In this study we evaluated the adverse effects of isotretinoin on liver functions and serum lipids with focus on the gender, age and isotretinoin dosages. Material and Methods: Medical re...

PURPOSE MicroRNA-122 (miR-122) has recently been shown to represent a novel biomarker of liver disease. However, the presence of serum miR-122 after liver injury was mostly studied at singular time points. The course of serum miR-122 was determined at consecutive time points during the onset of disease. METHODS Fulminant hepatitis was induced by a high-copper diet in Long-Evans Cinnamon (LEC)...

BACKGROUND The metabolic syndrome and non-alcoholic fatty liver disease are increasing at alarming rates. AIMS To determine the effect of HMG-CoA reductase inhibitors (statins) on elevated liver enzymes in patients with hyperlipidemia. PATIENTS Patients with AST above 60 U/L prior to or during treatment with statin therapy at a quaternary care lipid clinic were reviewed. METHODS A retrosp...