We examined expression of B cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) and a proliferation-inducing ligand (APRIL) on chronic lymphocytic leukemia (CLL) B cells and nurselike cells (NLCs), which differentiate from CD14+ cells when cultured with CLL B cells. NLCs expressed significantly higher levels of APRIL than monocytes and significantly higher levels of BAFF and...

Pneumonia is a serious respiratory tract infection disease in children, which threatens to the health or life of children patients. Ginsenoside Rb1 (Rb1) principle active ingredient extracted from root Panax notoginseng (Burk.) F.H. Chen with anti-inflammatory effect. Our study aimed determine effects and molecular mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury lung fibrobla...

Immune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators targeting critical molecules cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features proteins, like a pleckstrin homology (PH) domain in N-terminal region Src 2 (SH2) central region. STAP-2 binds...

Abstract T Cell Factor 1, or TCF1, is a transcription factor required for thymic cell development, memory formation, and maintenance of exhausted/dysfunctional stem/progenitors in tumors chronic infection. However, TCF1 regulation function during activation not well-understood. We analyzed the expression kinetics Tcf7 mRNA, encoding (RNA-SEQ) protein (flow cytometry western immunoblotting) CD8 ...

Besides its involvement in clot lysis, the plasminogen activator (PA) system elicits various cellular responses involved in cell migration, adhesion, and proliferation and plays a key role in the progression of cancers. B-Catenin interacts with E-cadherins and functions as transcriptional coactivator of the Wnt-signaling pathway, which is implicated in tumor formation when aberrantly activated....

B cell terminal differentiation involves development into an antibody-secreting plasma cell, reflecting the concerted activation of proplasma cell transcriptional regulators, such as Blimp-1, IRF-4, and Xbp-1. Here, we show that the microphthalmia-associated transcription factor (Mitf) is highly expressed in naive B cells, where it antagonizes the process of terminal differentiation through the...