neural cell adhesion molecules (ncams) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. this study investigated the possible role of camp pathway in the expression of hippocampal ncam and its polysialylated derivative (psa-ncam). the following pharmacological tools were employed for manipulation of camp pathway: a) forskolin; the activator of ...

Tumor necrosis factor receptor 1 (TNFR1) activates NF-?B–dependent pro-inflammatory gene expression, but also induces cell death by triggering apoptosis and necroptosis. Inhibition of inhibitor NF-?B kinase (IKK)/NF-?B signaling in keratinocytes paradoxically unleashed spontaneous TNFR1-mediated skin inflammation mice, the underlying mechanisms remain poorly understood. Here, we show that TNFR1...

development of inhibitor to factor viii is the most serious complication of hemophilia therapy. to determine the prevalence of inhibitors in iran hemophilia a patients exposed to blood products, 1280 hemophilia a patients (age range 9 months-84 years) were evaluated. all patients received several blood products such as fresh frozen plasma (ffp), cryoprecipitate, and factor viii. 635 of 1280 pat...

Phosphoinositide 3-kinases (PI3K) are key signaling enzymes regulating cellular survival, development, and function. Expression of the PI3Kδ isoform is largely restricted to leukocytes and it plays a key role in immune cell development and function. Seletalisib is a novel small-molecule inhibitor of PI3Kδ that was evaluated in biochemical assays, cellular assays of adaptive and innate immunity,...

Background Although biological therapies have transformed the outlook for those with rheumatoid arthritis, there is a lack of any meaningful response in approximately 40% patients. The role B cells arthritis pathogenesis well recognised and supported by clinical efficacy B-cell-depleting agent rituximab (MabThera, F. Hoffman La-Roche Ltd, Basel, Switzerland). Rituximab licensed use following fa...

Thrombotic thrombocytopenic purpura (TTP) is mostly attributed to the presence of an autoantibody against ADAMTS-13, a metalloprotease that degrades ultralarge von Willebrand protein multimers. Accumulation of vWF multimers and systemic platelet aggregation lead to microangiopathic thrombosis, hemolytic anemia, and end-organ ischemia. Most patients respond to therapeutic plasma exchange (TPE), ...

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Despite aggressive treatment regimen B-Cell Chronic Lymphocytic Leukemia (CLL) is still incurable. Previously we defined the role of a novel receptor tyrosine kinase (RTK) Axl in CLL B-cell survival. In this study we demonstrated the impact of Axl inhibition on CLL B-cell survival using a high-...

Background: Chemotherapy forms the backbone of treatment for Diffuse Large B Cell Lymphoma (DLBCL); however, <∼20% tumors are chemoresistant. Inhibitors DNA damage response (DDR) show promise as chemosensitizers. We therefore set up an in-vitro screen to identify optimal chemotherapy-DDR inhibitor (DDRi) combination in a panel DLBCL cell lines. Material and Methods: To achieve this, we harnesse...