Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer's disease (LOAD) risk and plasma amyloid β (Aβ) levels. In-vitro knock-down of LRRTM3 was previously shown to decrease secreted Aβ, although the mechanism of this is unclear. In SH-SY5Y cells ove...

β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) initiates the production of β-amyloid (Aβ), the major constituent of amyloid plaques in Alzheimer's disease (AD). BACE1 is elevated ∼2-3 fold in AD brain and is concentrated in dystrophic neurites near plaques, suggesting BACE1 elevation is Aβ-dependent. Previously, we showed that phosphorylation of the translation initiation fact...

BACKGROUND Beta-secretase 1 (BACE1) is a rate-limiting enzyme in the generation of amyloid beta peptides, which are associated with Alzheimer's disease (AD). It has been reported that Schisandrin B could improve cognitive functions in animal models of AD, but the underlying mechanisms are not completely understood. MATERIAL AND METHODS In this research, in order to investigate the effects of Sc...

Alzheimer’s disease (AD) is one of the most common progressive neurodegenerative diseases that represents about 60-80 % total cases dementia all over world. Beta secretase (BACE1) a membrane-anchored aspartic protease which cleaves peptide bond between Met671-Asp672 APP (amyloid precursor protein) where its activity rate limiting step producing amyloid β, primary neuropathological hallmark Alzh...

The beta-amyloid peptide (Abeta) is a major component of the Alzheimer's disease (AD)-associated senile plaques and is generated by sequential cleavage of the beta-amyloid precursor protein (APP) by beta-secretase and gamma-secretase. Since BACE1 initiates Abeta generation it represents a valuable target to interfere with Abeta production and treatment of AD. While the enzymatic activity of BAC...

Proteins of the Seizure protein 6 (Sez6) family are abundant in neurons and are localized to the somatodendritic compartment of these highly polarised cells (Gunnersen et al., 2007; Miyazaki et al., 2006). Two recent studies (Kuhn et al., 2012; Pigoni et al., 2016) highlight the important role of the Alzheimer’s disease (AD)-linked aspartyl-protease β-site amyloid precursor protein (APP) cleavi...

of APP expression and processing in vivo, we used brain and cerebral microvessels from eNOS-deficient (eNOS / ) mice. Brain tissue from eNOS / mice had statistically higher APP and BACE1 protein levels, as well as increased BACE1 enzyme activity and A (A 1-42 wild-type control, 0.737pg/mg; eNOS / , 1.475 pg/mg; P<0.05), compared with wild-type controls (n 6 to 8 animals per background). Brain m...

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by pathological brain lesions and a decline in cognitive function. β-Amyloid peptides (Aβ), derived from proteolytic processing of amyloid precursor protein (APP), play a central role in AD pathogenesis. β-Site APP cleaving enzyme 1 (BACE1), the transmembrane aspartyl protease which initiates Aβ production, is ax...

The b-amyloid peptide (Ab) is a major component of the Alzheimer’s disease (AD)-associated senile plaques and is generated by sequential cleavage of the b-amyloid precursor protein (APP) by b-secretase and g-secretase. Since BACE1 initiates Ab generation it represents a valuable target to interfere with Ab production and treatment of AD. While the enzymatic activity of BACE1 resides in the extr...

BACKGROUND Aging is associated with the gradual cognitive decline and shows the typical senile plaque formation in the brain, which results from the aggregation of beta amyloid (Aβ) peptide following the abnormal proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase. Accumulating evidence indicates that several microRNAs (miRNAs) are involved in the Al...