Background : An accurate and prompt diagnosis of bacterial arthritis is essential for earlier treatment and a good outcome. Superantigens produced by Staph. Aureus are among the most lethal toxins. The paper objective was Identification of common bacterial antigens and S.aureus superantigens in synovial fluid (SF) of children with negative culture and direct smear for other bacteria except fo...

Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled free fatty acid 2 (FFA2) receptor, and this has been suggested as a therapeutic target for the treatment of both metabolic and inflammatory diseases. However, a lack of understanding of the molecular determinants dictating h...

Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [110]) are activated endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for antagonist-bound [153, 313, 221, 61], agonist-bound [375, 203, 204] and G protein-bound A2A [49] have been described. The of an A1 receptor [128] adenosine-bound receptor-Gi complex [86] resolve...

Quorum sensing is a cell-to-cell signaling mechanism in which bacteria respond to hormone-like molecules called autoinducers (AIs). The AI-3 quorum-sensing system is also involved in interkingdom signaling with the eukaryotic hormones epinephrine/norepinephrine. This signaling activates transcription of virulence genes in enterohemorrhagic Escherichia coli O157:H7. However, this signaling syste...

aims: the internal unit and icu of hospitals are a suitable environment for growing of bacteria such as staphylococcus epidermidis, pseudomonas and acinetobacters. the aim of this study was to evaluate the efficacy of using disinfectants on bacterial remove in isfahan city, iran, hospitals. instrument & methods: this descriptive study was performed in isfahan city, iran, hospitals in 2015. 200 ...

background: since increased lh in the early follicular phase in pcos patients especially in gnrh antagonist protocol could be associated with reduced oocyte quality and pregnancy and impared implantation. the current study was conducted to determine art outcomes in gnrh antagonist protocol (flexible) and long gnrh agonist protocol and compare them with adding gnrh antagonist in gnrh antagonist ...

the effect of short term usage of gnrh antagonist as pretreatment on superovulation in goats was evaluated. statistical analysis was performed using t-test and showed that usage of gnrh antagonist as pretreatment can improve number of recovered embryos (p0.05). this study showed that usage of gnrh antagonist can improve superovulatory response in term of embryo recovery in goats .this study sho...

conclusions we observed acceptable results regarding both efficacy and safety with 62.5 mg of bosentan, twice daily in this group of patients. further clinical trials investigating pah with lower dosages of bosentan may be warranted. results no adverse drug reaction was observed during the follow-up. clinical worsening occurred in six (14%) patients, at least one year after treatment, two of th...

abstract the gnrh analogue (agonist and antagonist gnrh) changed ovarian stimulation. on the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. this leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (ohss). on the other hand, the gnrh analogue can prevent the incidence of ohss: gnrh antagonist protocols, gnrh...

Bacterial chemotaxis signaling is triggered by binding of chemo-effectors to the membrane-bound chemoreceptor dimers. Though much is known about the structure of the chemoreceptors, details of the receptor dynamics and their effects on signaling are still unclear. Here, by using molecular dynamics simulations and principle component analysis, we study the dynamics of the periplasmic domain of a...