نتایج جستجو برای: bad gene
تعداد نتایج: 1170207 فیلتر نتایج به سال:
We explore the use of the Spiral Array spatial visualization of tonal evolution through time for the visual analysis of P.D.Q. Bach’s The ShortTempered Clavier. In particular, we analyze situations in which we can see some of the humour devices abstracted in an earlier study by David Huron. We conclude that although we can see a good number of Schickele’s humour devices − such as incongruent st...
We demonstrate that deregulation in the form of vertical separation of network components into natural monopoly and potentially competitive markets does not truly represent a lessening of regulatory burdens. That is, vertical separation is not synonymous with deregulation; “more competitors” is not equivalent to “more competition”. We assume a public interest regulator that is constrained to se...
This paper extends the political agency approach to an environment in which voting may be divided between informed and instrumental, informed and ‘expressive’ and uninformed due to ‘rational irrationality’. It constructs a model where politicians may be good, bad or populist. Initially the existence of only good and populist politicians is assumed and the incentives for good politicians to pool...
Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias. We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated apoptotic pathway. Imatinib activated several proapoptotic BH3-only proteins: bim and bmf transcription was increased, and both Bim and Bad were activated posttranslationally. Studies using RNAi and cells from gen...
Here we show that LNCaP, which is resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, becomes sensitive to TRAIL after overexpression of full-length, wild-type BAD (BAD WT). TRAIL induces caspase-dependent cleavage of BAD WT that results in generation of a M(r) 15,000 protein. LNCaP stably expressing truncated BAD (tBAD) and cells expressing mutated B...
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