PURPOSE To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti-TNF-α antibody administration. METHODS A DDS was fabricated using inverse template fabrication of a hydrophobic three-dimensional porous scaffold (100-300 μm in diameter porosity) loaded with 10% polyvinyl alcohol hydrogel carrying 5 mg/ml (weight/volume) of ant...

A one-dimensional drug delivery system (1D DDS) is highly attractive since it has distinct advantages such as enhanced drug efficiency and better pharmacokinetics. However, drugs in 1D DDSs are all encapsulated in inert carriers, and problems such as low drug loading content and possible undesirable side effects caused by the carriers remain a serious challenge. In this paper, a novel, carrier-...

A 66-year-old man with severe renal insufficiency presented with mild confusion associated with uremia. Cranial magnetic resonance imaging (MRI) showed no remarkable changes. The patient was placed on short-duration hemodialysis (2 hours) with smaller surface area and low blood flow (100 mL/min) to avoid dialysis disequilibrium syndrome (DDS). His consciousness gradually improved and he did not...

Multiple-valued decision diagrams (MDDs) give a way of approaching problems by using symbolic variables which are often more naturally associated with the problem statement than the variables obtained by a binary encoding. We present a more general class of MDDs, containing not only branching nodes but also functional nodes, labeled by addition modulo p operation, p prime, and give algorithms f...

In this paperwe present the StrategyGeneric ExtensibleModelchecker (StrataGEM), a tool aimed at the analysis of Petri nets and other models of concurrency by means of symbolic model-checking techniques. StrataGEMmarries the well know concepts of TermRewriting (TR) to the efficiency of Decision Diagrams (DDs). TR systems are a great way to describe the semantics of a system, being readable and c...

To cope with the complexity of today’s digital systems in diagnostic modelling, hierarchical approaches should be used. In this paper, the possibilities of using Decision Diagrams (DD) for diagnostic modelling of digital systems are discussed. DDs can be used for modelling systems at different levels of representation like logic level, register transfer level, instruction set level. The nodes i...

In decision diagrams (DDs) methods for circuit synthesis, it is possible to directly transfer a DD for a given function f into a network realizing f by the replacement of non-terminal nodes in the DD with the corresponding circuit modules. The chief bottleneck of mapping a DD into a network is the inherent feature that the depth of the network produced, is equal to the number of variables in f....

The purpose of the present study was twofold: 1) to determine if antibodies raised against ubiquitin would recognize antigens associated with the porcine cytoplasmic droplet (CD), and 2) to determine if the same antibody would identify ubiquitinated substrates on the surface of morphologically abnormal boar spermatozoa. Permeabilization with the detergent Triton X-100 (0.05%) showed virtually a...

Efficient methods for the representation and simulation of quantum states operations are crucial optimization circuits. Decision diagrams (DDs), a well-studied data structure originally used to represent Boolean functions, have proven capable capturing relevant aspects systems, but their limits not well understood. In this work, we investigate bridge gap between existing DD-based structures sta...