BACKGROUND With the appearance of oral direct-acting antivirals (DAAs), the field of hepatitis C virus (HCV) treatment has been dramatically changed. This evolution makes possible for all oral treatments to be available for the treatment of HCV-infected patients. The aims of this review were to report the efficacy and safety of sofosbuvir (SOF)-based regimens for the treatment of patients with ...

BACKGROUND Ribavirin (RBV) is a potential partner of interferon-based therapy and recently approved therapy using direct acting antivirals for patients with chronic hepatitis C. However, the precise mechanisms underlying RBV action against hepatitis C virus (HCV) replication are not yet understood. To clarify this point, we attempted to develop RBV-resistant cells from RBV-sensitive HCV RNA-rep...

The chapter is a systematic literature review of fundamental theories about small and medium business (SME) success. examines how they specifically impact digital SMEs. examined six theories: dynamic capability view (DCV), composition-based firm growth (CBV), resource-based (RBV), resource dependence theory (RDT), upper echelon (UET), strategic contingency (SCT). results showed that RBV, DCV, U...

Purpose A total of 210 valid paper-and-pencil questionnaires were received from fast-moving consumer goods/small and medium-sized enterprises (FMCG-SMEs) to empirically test the proposed model. Structural equation modelling approach was performed assess model fit, measurement structural models for exogenous endogenous constructs, nonlinearity. Design/methodology/approach In hyper-competitive wo...

Purpose: This conceptual paper explores the relationship between generation of logistics service providers (LSPs), scope LSP supply chain performance measurement system (LSP SCPMS), and corresponding impact on (SC) performance. We propose that among LSPs applying SCPMSs, may affect SCPMS, which influence SC Building extant research, we present a framework, with agency theory incorporating risk ...

Ribavirin (RBV) is a synthetic nucleoside analog with broad spectrum antiviral activity. Although RBV is approved for the treatment of hepatitis C virus, respiratory syncytial virus, and Lassa fever virus infections, its mechanism of action and therapeutic efficacy remains highly controversial. Recent reports show that the development of cell-based resistance after continuous RBV treatment via ...

NetSourcing has recently gained some importance in the IS literature. However, although the customer side of Netsourcing has drawn a lot of interest, its supply-side remains under-researched. One of the challenges faced by Netsourcing vendors is the difficulty in sourcing the components of the infrastructure on which they rely. This paper proposes to investigate the sourcing strategies used by ...

BACKGROUND The manner in which ribavirin (RBV) enhances the antiviral effects of interferon (IFN) against hepatitis C virus (HCV) remains unknown. We investigated whether RBV modifies IFN-stimulated genes (ISGs) in vivo and in vitro. METHODS We measured the messenger RNA (mRNA) levels of ISGs in T lymphocytes from patients with HCV infection who were receiving IFN-α therapy with or without RB...

We introduce a novel method for reconstructing the 3D geometry of botanical trees from single photographs. Faithfully tree single-view sensor data is challenging and open problem because many possible exist that fit tree's shape observed view. address this challenge by defining reconstruction pipeline based on three neural networks. The networks simultaneously mask out in input photographs, ide...

The global outsourcing industry, including the Human Resources (HR) Systems outsourcing industry is growing at a phenomenal rate. The proponents of the resource-based view (RBV) have long argued that a firm gains sustainable competitive advantage from those resources and capabilities it controls and which are valuable, rare, imperfectly imitable, and not substitutable. The RBV also indicates th...