non-hodgkin lymphoma usually presents with generalized lymphadenopathy, but it can also involve any part of the human body. lymphomatous involvement of muscles is a rare presentation and has been reported to occur in only 1.1% in non-hodgkin lymphoma. here we, present a 32 year-old iranian man with primary involvement of spleen, bone, bone marrow and muscle, mimicking soft tissue sarcoma; core ...

Sjögren’s Syndrome (SS) is an autoimmune disease characterized by chronic Band T-cell infiltration of the salivary and lachrymal glands. Clusters of Band Tcells which resemble germinal centres are seen within the glandular tissue. We have shown that clonal Bcell proliferation and affinity maturation are occurring within these clusters [1]. ScFv antibodies have been produced from one of these B-...

Submit Manuscript | http://medcraveonline.com Abbreviations: AGE: Advanced Glycation End-Product; Angii: Angiotensin II; CAD: Coronary Artery Disease; Dia-1: Diaphanous-1; DN: Dominant-Negative; Hba1c: Glycated Haemoglobin; HMGB1: High-Mobility Group Box-1; LTA: Lymphotoxin Α; NF-Κb: Nuclear Factor Κb; NMD: Nonsense-Mediated Mrna-Decay; PBX2: Pre-BCell Leukaemia Homeobox 5; RAGE: Receptor for A...

Introduction: Burkitt lymphoma (BL) is rare, but an aggressive malignancy. Central nervous system Burkitt lymphoma (CNSBL) is very rare. CNS Burkitt’s lymphoma is treated with high-dose chemotherapy and radiation. Radiotherapy in children younger than three years old may cause major CNS damage. Case report: A three-year-old boy presented with painful proptosis of the left eye. He under...

INTRODUCTION Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR) and Fc receptors, which are important for the development and function of lymphoid cells. Given the clinical efficacy of Bcell depletion in the treatment of rheumatoid arthritis and multiple sclerosis, pharmacological modulation of Bcells...

introduction: burkitt lymphoma (bl) is rare, but an aggressive malignancy. central nervous system burkitt lymphoma (cnsbl) is very rare. cns burkitt’s lymphoma is treated with high-dose chemotherapy and radiation. radiotherapy in children younger than three years old may cause major cns damage. case report: a three-year-old boy presented with painful proptosis of the left eye. he underwent aden...

Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma consisting of lymphoid cells that are usually bizarre and large CD30-positive cells with abundant cytoplasm and pleomorphic nuclei. At present, two types of ALCL are recognized, that is, anaplastic lymphoma kinase (ALK)positive ALCL (ALCL, ALK ) and ALK-negative ALCL (ALCL, ALK−), although they are not morphologically distinguishab...

most bladder tumors are epithelial in origin. nonepithelial cancers are rarely located in the bladder. sarcomas are the most common malignancies among nonepithelial cancers. primary bladder lymphoma is rare and mostly low grade. here, we have reported a case of diffuse large cell lymphoma of the bladder. the patient, a 64-year-old man, had urinary frequency for 18 months. abdominal sonography i...

Introduction: This study is aimed to assess the prevalence and characteristics of head and neck lymphoma in a defined group of an Iranian population.   Materials and Methods: In this retrospective study, 126,450 biopsy reports from two referral Pathology Departments, (Tehran, the capital of Iran) were evaluated. In cases with head and neck lymphoma, other variables such as age, sex, specific lo...