Objective(s): The beneficial and more potent role of exercise to prevent heart apoptosis in ovariectomized rats has been known. The aim of this study was to examine the effects of swimming training on cardiac expression of Bcl-2, and Mir-133 levels and glycogen changes in the myocyte. Materials and Methods: Forty animals were separated into four groups as control, sham, ovariectomy (OVX) and o...

Currently, it has been suggested that human mesenchymal stem cells (MSCs), a well-known multipotent cells, could modify the biological process in leukemia cells. Therefore, we evaluated MSCs’ possible effects on apoptosis and proliferation of acute lymphoblastic (ALL) MOLT-4 Accordingly, were co-cultured with MSCs. Then, 24, 48, 72 hours after treatment, percentages cell was estimated using flo...

objective(s): the beneficial and more potent role of exercise to prevent heart apoptosis in ovariectomized rats has been known. the aim of this study was to examine the effects of swimming training on cardiac expression of bcl-2, and mir-133 levels and glycogen changes in the myocyte. materials and methods: forty animals were separated into four groups as control, sham, ovariectomy (ovx) and ov...

the study was conducted to evaluate the effect of thermal stress on expression profile of genes related to apoptosis in peripartum sahiwal cows. for this, twelve pregnant dry sahiwal cows were selected from livestock research centre at national dairy research institute, karnal. the cows were divided into two groups consisting of six sahiwal cows each. cows of group i calved during thermoneutral...

objective: to evaluate the mrna expression ratio of bcl-2/bax both in normal and tumoral bladder tissues of patients with transitional cell carcinoma (tcc) of bladder and investigate potential correlation between this expression ratio and clinical outcome. materials and methods: in this experimental study, we used real time-pcr to investigate the expression of bcl-2 and bax both in normal and t...

background:   materials and methods: this was a cross-sectional study carried out among 70 samples, including 10 samples from normal healthy mucosa categorized into group 1, group 2 (30 olp), and group 3 (30 oed) samples. five sections (4 μm thick) were obtained and stained with monoclonal antibodies such as ki-67, p53, bcl-2, and bax and analyzed for number of positive cells and also for inten...

Abstract B-cell lymphoma X-large (BCL-XL) has been shown to promote breast cancer metastasis independently of its anti-apoptotic function. We recently found that proteolysis-targeting chimeras (PROTACs) against BCL-XL kill cells as well tumor-induced regulatory T (TI-Tregs). BCL-XL-targeting PROTACs can be potentially used treat metastatic – by direct killing circulating tumor at their vulnerab...