Methods In this study, the VHC called Tipshaler (Protec’som, France) was evaluated with fluticasone (Flixotide, 50μg/dose, GSK, France) and beclomethasone (QVAR, 100μg/dose, MEDICIS, Canada). The method according to the European Pharmacopoeia used a constant flow rate (30 L / min) was used. Particle size distribution was measured using a NGI cascade impactor (Copley Scientific, Nottingham, Unit...

Of 16 steroid-dependent asthmatic patients oral treatment has been discontinued in six and reduced in four after the introduction of beclomethasone dipropionate. Substitution of inhaled beclomethasone for oral steroids was unsuccessful in the remaining six patients. Serial adrenal function studies in the patients whose oral treatment was discontinued showed progressive recovery, and five out of...

M e t h o d s Design: Randomized controlled trial (Beclomethasone plus Salbutamol Treatment [BEST] study). Allocation: Unclear allocation concealment.* Blinding: Blinded (unclear).* Follow-up period: 6 months. Setting: 25 centers in Italy, Austria, Poland, and Spain. Patients: 466 patients, 18 to 65 years of age, with mild, persistent asthma for ≥ 6 months, prebronchodilator FEV1≥ 75% of predic...

This study was performed to determine the effects of high doses of two inhaled corticosteroids, beclomethasone dipropionate and budesonide, on biochemical indices of bone turnover (urinary hydroxyproline:creatine and calcium:creatinine ratios, plasma alkaline phosphatase, and parathyroid hormone). Twelve healthy male doctors, aged 25-36 (mean 30) years, were studied. After a week's run in perio...

INTRODUCTION Post-operative sore throat and cough are common complications of endotracheal intubation. These conditions may be very distressing for the patient and may lead to unpleasant memories. This study was performed in order to determine whether beclomethasone and lidocaine spray could reduce the frequency of post-operative sore throat and hoarseness after tracheal extubation. MATERIALS...

Bloodspot cortisol, where finger pricked blood is applied to blotting paper, is suitable for repeated measurements in the home environment. The use of bloodspot cortisol measurements in children with asthma and the effect of inhaled corticosteroids on daytime cortisol concentrations were assessed. Twenty children with mild asthma were randomised to receive double blind either placebo or beclome...

The effects of controlling childhood asthma of the same daily dose (400 pg) of beclomethasone dipropionate, given in two or four equal divided doses from a metered aerosol, were compared in a double blind crossover study. Thirty one children aged 6-14 years completed the study. They had previously been shown to need beclomethasone by showing either symptoms or reduced peak flow when the treatme...