Recovery is emerging as an influential but ill-defined organizing concept for addiction treatment and the larger field of behavioral health care. The reification of the concept of recovery is discounted by some as nothing new ("We're already recovery oriented."), an ephemeral fad lacking substance and import ("This is old wine in a new wineskin."), or as hopelessly impractical ("Nobody will pay...

Injury due to stroke and traumatic brain injury result in significant long-term effects upon behavioral functioning. One central question to rehabilitation research is whether the nature of behavioral improvement observed is due to recovery or the development of compensatory mechanisms. The nature of functional improvement can be viewed from the perspective of behavioral changes or changes in n...

Extreme over-reliance on the impaired forelimb following unilateral lesions of the forelimb representation area of the rat sensorimotor cortex (FL-SMC) leads to exaggeration of injury when overuse is begun during the first week, but not later periods, after injury. Behavioral impairment is partially worsened by the additional tissue loss. In the present study, we show that complete disuse of th...

Several approaches exist for modeling recovery of faulttolerant systems during the requirements analysis phase. Most of these approaches are inclined by design techniques for recovery. Such designbiased analysis methods unnecessarily constrain an analyst when specifying recovery requirements. To remedy such restrictions, we present an object analysis pattern, called the corrector pattern, that ...

The purpose of this investigation was to determine whether sequential (i.e., serial) ablation of the monkey’s orbital prefrontal cortex would lead to a reduction in the severity of the behavioral impairment usually associated with one-stage bilateral removal of this tissue. The lateral orbital cortex was ablated in four operations spaced 3 weeks apart or in a one-stage procedure. The monkeys we...

Several experimental models of cervical spinal cord injury (SCI) have been developed recently to assess the consequences of damage to this level of the spinal cord (Pearse et al., 2005, Gensel et al., 2006, Anderson et al., 2009), as the majority of human SCI occur here (Young, 2010; www.sci-info-pages.com). Behavioral deficits include loss of forelimb function due to damage to the white matter...

BACKGROUND AND PURPOSE The relation between recovery of brain function and neurological status after clinical and experimental cerebral ischemia is incompletely characterized. We assessed the evolution of ischemic injury, behavioral status, and brain activity at acute to chronic periods after transient middle cerebral artery occlusion (tMCAO) in rats. METHODS Male Sprague-Dawley rats were sub...

Introduction : bipolar affective disorder frequently presents residual symptoms even in interictal period, what its turn causes problems psychosocial functioning, cognitive impairment and poor quality of life. Nowadays, the treatment targets are focused not only on clinical remission, but also functional recovery personal recovery, patients’ Scientific review contains results researches, aimed ...

Stroke is a leading cause of permanent disability and death. It is well accepted that the principal mammalian estrogen (E2), 17-β estradiol, provides robust neuroprotection in a variety of brain injury models in animals of both sexes. E2 enhances neurogenesis after stroke in the subventricular zone; however, it is unknown if these cells survive long-term or enhance functional recovery. In this ...

Adult, male, albino rats were trained to discriminate between two patterned stimuli in a T-maze. Performance on this task was assessed following intravitreal injection of 1 mumol glutamate. Discrimination performance declined to nearly random levels by 1 day postinjection and remained significantly depressed for 2 weeks. However, by 2 months after injection, there was evidence of behavioral rec...