this study a novel high performance liquid chromatography for the assay of nystatin in oral and vaginal tablets were optimized and validated using box–behnken experimental design. the method was performed in the isocratic mode on a rp-18 column (30 °c) using a mobile phase consisting of 0.05 m ammonium acetate buffer/ methanol mixture (30:70) and a flow-rate of 1.0 ml/min. the method was valida...

This paper proposes a research methodology, Lab-based Action Design Research, which combines organizational intervention (action research), building innovative artifacts (engineering research) and studies of software development practice (behavioral research) within a laboratory environment. Seven principles for successful Lab-based Action Design Research are proposed – attract funding with a w...

ANALYSIS OF MICRORNA MICROARRA Y (MM CHIP) DATA FOR AGING MICE MODELS Vikranth Shetty August 2nd, 2012 The present experimental designs have unique challenges in the analysis of microRNA expression intensity levels. In this project, various Normalization techniques were discussed with different statistical techniques and their application in an analysis performed at the Genes Centre of aging on...

in the present study, an ultrafine grained (ufg) 304l stainless steel with the average grain size of 300 nm was produced by a combination of cold rolling and annealing. weldability of the ufg sample was studied by nd: yag laser welding under different welding conditions. taguchi experimental design was used to optimize the effect of frequency, welding time, laser current and laser pulse duratio...

spinel-type of mno2 nanoparticles which successfully synthesized by a hydrothermal process, have a required capacity for lithium uptake from liquid resources. themost lithium adsorption capacity of 6.6 mmol/g of up to now was found to be an important limiting parameter for industrial applications. therefore, increasing uptake capacity of these ion sieves by studding the effect of six effective ...

in this study, taguchi experimental design has been used for the optimization of thickness of chromium layers. for this purpose brass materials have been electroplated under various conditions of the process. an orthogonal array (oa) was employed to analyze the effect of plating parameters on the characteristic of the thickness. variables which were considered for working were as following; amo...

The main goal of microarray experiments is to select a small subset of genes that are differentially expressed among competing mRNA samples. For a given set of such mRNA samples, it is possible to consider a number of two-color cDNA microarray designs with a fixed number of arrays. Appropriate criteria can be used to select an efficient design from such a set of alternative experimental designs...

A primary advantage of functional magnetic resonance imaging (fMRI) over other techniques in neuroscience is its flexibility. Researchers have used fMRI to study a remarkable diversity of topics, from basic processes of perception and memory, to the complex mechanisms of economic decision making and moral cognition. The chief contributor to this experimental flexibility-indeed, to the growth of...