Abstract Inflammatory arthritides such as rheumatoid arthritis are a major cause of disability. Pre-clinical murine models inflammatory continue to be invaluable tools with which identify and validate therapeutic targets compounds. The used well-characterised and, whilst none truly recapitulates the human disease, they crucial researchers seeking novel test efficacy during preclinical trials dr...

Abstract The ESR1 ligand–binding mutations were unveiled a number of years ago and are the most common genetic mechanism acquired resistance to endocrine treatment, particularly, aromatase inhibitors. discovery these was enabled after advancements in sequencing technologies when metastatic tissue samples interrogated. domain activating that lead constitutive ligand-independent activity, which e...

The nutritional health in the world is one of the most pressing issues facing different countries today. International organizations like FAO and WHO suggest that there is an improvement of the nutritional situation in Asia and Latin America, though a deterioration in Sub-Saharan Africa does exist. As regards Europe and USA, we are living in the era of " overnutrition. " Unfortunately, the situ...

Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate immune response. Chemokine-dependent signaling in immune cells is a very important mechanism leading to integrin activation and leukocyte recruitment. CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. During the last years, several studies were performed investigatin...