Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton pump inhibitors, antihypertensives, anticoagulants, immunomodulators, hormone modulators, CNS stimulants as well as depressants, lipid level modulators, antidiabetics, etc. has made it an indispensable anchor for de...

The design, synthesis, and in vitro antiproliferative activity of a novel series of sulfide (4a-i) and sulfoxide (5a-h) derivatives of benzimidazole, in which different aromatic and heteroaromatic acetamides are linked to benzimidazole via sulfide (4a-i) and sulfoxide (5a-h) linker, are reported and the structure-activity relationship is discussed. The new derivatives were prepared by coupling ...

A novel series of indole and benzimidazole bichalcophene diamidine derivatives were prepared to study their antimicrobial activity against the tropical parasites causing African sleeping sickness and malaria. The dicyanoindoles needed to synthesize the target diamidines were obtained through Stille coupling reactions while the bis-cyanobenzimidazoles intermediates were made via condensation/cyc...

In recent years, the use of antifungal drugs in human medicine has increased, especially with the advent of AIDS epidemic. Efforts have focused on the development of new, less toxic and more efficacious antifungal drugs with novel mechanism of action. The purpose of this study was to synthesize of some new benzimidazole, benzotriazole and aminothiazole derivatives and to evaluate their activity...

RATIONALE Benzimidazoles and its derivatives represent one of the mainly biological active classes of literature. AIM In this present study aimed to synthesize N-mannich bases derivatives compounds bearing of 2-substituted benzimidazole moiety, in order to investigate their possible biological activity. METHOD Benzimidazole compounds were prepared from the condensation reaction between orth...

In the present study some substituted benzimidazole derivatives were screened for several biological activities. The synthesized compounds subjected to evaluation of central analgesic, anti-inflammatory, cytotoxicity, antimicrobial and antioxidant activities by radiant heat induced tail flicking, carrageenan rat paw edema inhibition, brine shrimp lethality bioassay, disc diffusion DPPH free rad...

We have obtained the X-ray crystal structure of galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline–galactoside ligand at resolution 1.6 Å. Based on this structure, collection galactosides derivatised O3 triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed synthesised. This led to discovery 3-O-(N-methylbenzimidazolylmethyl)–galactoside Kd 1...

A set of benzimidazole derivatives were tested for their inhibitory activities against the Gram-negative bacterium Pseudomonas aeruginosa and minimum inhibitory concentrations were determined for all the compounds. Quantitative structure activity relationship (QSAR) analysis was applied to fourteen of the above mentioned derivatives using a combination of various physicochemical, steric, electr...