نتایج جستجو برای: bexarotene
تعداد نتایج: 288 فیلتر نتایج به سال:
RAC-alpha serine/threonine-protein kinase (Akt-1) is an enzyme encoded by AKT1 gene in Homo sapiens. Akt-1 is responsible for regulating many cellular processes. An increase in Akt-1 activity inhibits apoptosis leading to cancer. Bexarotene, a retinoid holds a promise to be used in inhibiting cancers. Hesperidin, a flavanoid, can act as an anticarcinogenic agent.. In the present study three-dim...
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) of the α/β type is a rare subtype of non-Hodgkin's lymphoma of the skin. Although these tumors usually run an indolent course, disease-related morbidity is often severe. Clinical findings include subcutaneous tumors located on the extremities or trunk, often accompanied by systemic symptoms like fever or fatigue. Due to the low incidence of ...
Thyrotropin (TSH) and, consequently, thyroid hormone secretion (thyroxine (T4) and tri-iodothyronine (T3)) is regulated by a negative feed-back mechanism which is exerted by T3 binding to its own receptor, located in the nucleus of the thyrotrope cells of the anterior pituitary gland. Thyroid hormone receptors (TRs) are known to mediate T3 suppression of TSH b-subunit gene (TSHb) expression, ac...
[This corrects the article DOI: 10.1371/journal.pone.0153150.].
Lung cancer has limited effective therapy and no effective prevention. Cytotoxic chemotherapy has not improved when combined with the epidermal growth factor receptor (EGFR) inhibitor erlotinib (standard lung cancer therapy) or with the rexinoid bexarotene. Combining erlotinib and bexarotene, however, to cotarget cyclin D1 via the retinoid X receptor and EGFR was active preclinically in KRAS-dr...
While skeletal myogenesis is tightly coordinated by myogenic regulatory factors including MyoD and myogenin, chromatin modifications have emerged as vital mechanisms of myogenic regulation. We have previously established that bexarotene, a clinically approved agonist of retinoid X receptor (RXR), promotes the specification and differentiation of skeletal muscle lineage. Here, we examine the gen...
Cutaneous T-cell lymphoma (CTCL) is an umbrella term that encompasses a group of neoplasms that have atypical T-lymphocytes in the skin. Mycosis fungoides (MF) is the most common type of CTCL and Sézary syndrome (SS) is the leukemic form. Treatment for CTCL is dependent on the stage of disease and response to previous therapy. Therapy is divided into skin-directed treatment, which tends to be f...
In this issue, Tsai et al. (1) report on a phase-I clinical trial of bexarotene in 27 non-M3 acute myeloid leukemia (AML). AML is characterized by abnormalities in the myeloid line at various stages of commitment and maturation, leading to an accumulation of granulocyte or monocyte precursors. The French, American, and British classification system divided the subtypes of AML, M0 through M7, ba...
Repurposing of existing cancer drugs to overcome their physical limitations, such as insolubility, represents an attractive strategy to achieve enhanced therapeutic efficacy and broaden the range of clinical applications. Such an approach also promises to offer substantial cost savings in drug development efforts. Here we repurposed FDA-approved topical agent bexarotene (Targretin), currently i...
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