The first example of the boron Lewis acid catalyzed C(sp2)-H functionalization of cyclic enones was achieved using diazoacetates. The insertion of the carbon atom of diazoacetates utilizes BF3•Et2O or a newly designed oxazaborolidinium ion as a catalyst to afford β-functionalized cyclic enones from simple cyclic enones in a single step and high yields. The reaction mechanism was investigated wi...

Schiff bases are aldehyde or ketone like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The reaction is acid catalysed, however only aldehydes and ketones which do not aldolize easily in acidic media, can be condensed with amines in presence of strong acid ca...

the knoevenagel condensation of aromatic aldehydes with barbituric acid, dimedone and malononitrile occurred in the presence of bf3/nano-γ-al2o3 at room temperature in ethanol. this catalyst is characterized by powder x-ray diffraction (xrd), fourier transform infrared spectroscopy (ft-ir), thermal gravimetric analysis (tga), field emission scanning electron microscopy (fesem) and energy-disper...

Usually, the ion implantation gases used in semiconductor production are required to be extremely high purity. Due presence of trace CO2 electronic special gas BF3, quality material is significantly affected, which makes it crucial impose control on content. Unlike a series blank adsorbents reported other studies, zinc-loaded prepared this study intended for adsorption from CO2/BF3. Firstly, ma...

A method for the synthesis of amide-containing molecules was developed using vinyl azides as an enamine-type nucleophile towards carbon electrophiles, such as imines, aldehydes, and carbocations that were generated from alcohols in the presence of BF3 ⋅OEt2 . After nucleophilic attack of the vinyl azide, a substituent of the resulting iminodiazonium ion intermediate migrates to form a nitrilium...

A novel bicyclization of 2-(2-(hydroxymethyl)-1-methylene-2,3-dihydro-1H-inden-2-yl)ethanol with aldehydes in the presence of 10 mol% BF3·OEt2 in dichloromethane at 0-25 °C affords the biologically relevant indeno[2,1-c]pyran scaffolds in good yields with high selectivity. Similarly the bicyclization of 2-(1-(hydroxymethyl)-2-methylenecyclopentyl)ethanol with aldehydes generates the correspondi...

The determination of the fatty acid composition (as methyl esters, FAMEs) of fats and oils and their cis/trans (CTME) distribution requires a simple, but manual and time-consuming sample preparation. The so-called BF3 method is often the preferred procedure. Because FAME/CTME analyses are encountered very frequently in the food industry, an automated, robot-based alternative is proposed which u...

The objective of the present study is to develop etoricoxib rapidly dissolving tablet formulations by wet granulation and direct compression methods employing starch phosphate, a new modified starch. As per FDA guidelines on biowaivers, drug products containing weakly acidic BCS class II drugs with a dissolution of > 85% in 30 min are eligible for biowaiver. Hence a dissolution of > 85% in 30 m...

Photoelectron diffraction is a well-established technique for structural characterization of solids, based on the interference of the native photoelectron wave with those scattered from the neighboring atoms. For isolated systems in the gas phase similar studies suffer from orders of magnitude lower signals due to the very small sample density. Here we present a detailed study of the vibrationa...