Summary Proteins are known to undergo structural changes upon binding partner proteins. However, the prevalence, extent, location, and function of change in protein dynamics due transient protein-protein interactions is not well documented. Here, we have analyzed a dataset 58 complexes three-dimensional structure structures their corresponding unbound forms evaluate induced by binding....

BACKGROUND When hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP) is caused by gram-positive and gram-negative pathogens or both (mixed infections), the adequacy of gram-negative coverage (GNC) can confound the assessment of a gram-positive agent under study. This analysis examines the influence of gram-negative infections and the adequacy of GNC on clinical efficacy an...

Metal ions play several major roles in proteins: structural, regulatory, and enzymatic. The binding of some metal increase stability proteins or protein domains. Some can regulate various cell processes being first, second, third messengers. ions, especially transition take part catalysis many enzymes. From ten to twelve metals are vitally important for activity living organisms: sodium, potass...

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (CRC). Therefore, it can be considered as a potential drug target.The aim of this study was to identify potential drug candidates ...

Background: Breast cancer is known as the most widely recognized dangerous tumors; therefore, the most common reason for mortality among all instances of harmful neoplastic illness in females. This is because the lack of specific signs and symptoms at the early stage and at the aggressive nature. Currently, breast cancer treatment such as chemotherapy, surgery and radiotherapy has not been effe...