We report from the second ESF Programme on Functional Genomics workshop on Data Integration, which covered topics including the status of biological pathways databases in existing consortia; pathways as part of bioinformatics infrastructures; design, creation and formalization of biological pathways databases; generating and supporting pathway data and interoperability of databases with other e...

Knowledge of the kinetics of biomolecular interactions is important for facilitating the study of cellular processes and underlying molecular events, and is essential for quantitative study and simulation of biological systems. Kinetic Data of Bio-molecular Interaction database (KDBI) has been developed to provide information about experimentally determined kinetic data of protein-protein, prot...

Understanding of cellular processes and underlying molecular events requires knowledge about different aspects of molecular interactions, networks of molecules and pathways in addition to the sequence, structure and function of individual molecules involved. Databases of interacting molecules, pathways and related chemical reaction equations have been developed. The kinetic data for these inter...

Glycoinformatics is a small but growing branch of bioinformatics and chemoinformatics. Various resources are now available that can be of use to glycobiologists, but also to chemists who work on the synthesis or analysis of carbohydrates. This article gives an overview of existing glyco-specific databases and tools, with a focus on their application to glycochemistry: Databases can provide info...

The paper focuses on bio®lms subject to turbulent ̄ow and high liquid velocity (of the order of 1 m s) which can be found in heat exchangers, water distribution systems and in some wastewater reactors. An overall model describing bio®lm development is presented, which includes the effects of biomass detachment due to the hydrodynamic forces. A methodology for estimating substrate consumption fr...

AIMS AND OBJECTIVES To provide evidence for the development of a physical domain attached to the well-known bio-psycho-social model of dementia. The objectives were to develop a set of international case studies that followed a trajectory approach, from prevention to end-of-life care. BACKGROUND In the UK the bio-psycho-social model has informed the shape of the National Institute for Health ...

Fast and accurate 3D object reconstruction and partial 3D component retrieval from 2D image slices represent a difficult and challenging problem. To group related objects on different layers in an image stack, image segmentation and sequential matching of adjacent 2D objects have to be preformed. Object matching involves heavy computing and is time consuming. In this paper, we propose a new app...

We have recently built a database system called BODHI, intended to store plant bio-diversity information. It is based on an object-oriented modeling approach and is developed completely around public-domain software. The unique feature of BODHI is that it seamlessly integrates diverse types of data, including taxonomic characteristics, spatial distributions, and genetic sequences, thereby spann...

Gravitactic bioconvective patterns created by Tetrahymena pyriformis in a Hele-Shaw apparatus were realized and compared with theoretical results. There were found to be two thresholds for bio-convection development: the first indicates the transition from the diffusion to the steady convection state; the second corresponds to the transition from the steady to the unsteady convection state. The...

Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relati...